Home LiteratureArticle Details
PMID: 8419082 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Immunoglobulin G subclass responses to mycobacterial lipoarabinomannan in HIV-infected and non-infected patients with tuberculosis.

Clinical and experimental immunology ·Vol. 91 ·No. 1 ·1993-01-00 ·Pages 25-9

Da Costa CT, Khanolkar-Young S, Elliott AM, Wasunna KM, McAdam KP

Abstract

Immunoglobulin G subclass responses to lipoarabinomannan (LAM) of Mycobacterium tuberculosis were determined by ELISA in both HIV-1 antibody positive (n = 31) and negative (n = 43) patients with tuberculosis (TB). Responses were also studied in a group of healthy controls (n = 16) and HIV-1 antibody positive (n = 60) individuals without TB. IgG2 antibodies were the predominant subclass, being present in 25 of 43 non-HIV-infected TB patients (58%) and in 11 of 31 HIV-infected TB patients (35%). However, HIV+ TB patients also showed IgG4 (n = 16; 52%), and IgG1 (n = 4, 13%) responses to LAM, whereas these subclasses were absent in sera from HIV-TB patients. Individuals in both non-tuberculous control groups showed no antibody responses to LAM. The influence of HIV infection on B cell responses to LAM, and possible mechanisms for antibody-mediated regulation of immunity to TB, are explored.

MeSH Terms
Adolescent Adult Antigens, Bacterial/immunology Female HIV Infections/complications,immunology Humans Immunoglobulin G/analysis,classification Lipopolysaccharides/immunology Male Mycobacterium/immunology Sex Factors Tuberculosis, Pulmonary/complications,immunology
Chemicals
Antigens, Bacterial Immunoglobulin G Lipopolysaccharides lipoarabinomannan
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Da Costa C T
Department of Clinical Sciences, London School of Hygiene & Tropical Medicine, UK.
Khanolkar-Young S
Elliott A M
Wasunna K M
McAdam K P
References (27)
27 references, click to expand
  1. Quantification of IgG subclasses in sera of normal adults and healthy children between 4 and 12 years of age.
    Clin Exp Immunol. 1975 Sep;21(3):501-9 PMID: 54236
  2. Interleukin-2 inhibits the interleukin-4-induced human IgE and IgG4 secretion in vivo.
    Clin Exp Immunol. 1991 Jun;84(3):400-5 PMID: 1904325
  3. Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response.
    J Immunol. 1983 Feb;130(2):722-6 PMID: 6600252
  4. A community survey of IgG4 antibody levels.
    Clin Allergy. 1983 Sep;13(5):397-407 PMID: 6605218
  5. Systemic antibody deficiency in patients without serum immunoglobulin deficiency or with selective IgA deficiency.
    Clin Exp Immunol. 1984 Apr;56(1):18-22 PMID: 6713729
  6. Plasma anti-pneumococcal antibody activity of the IgG class and subclasses in otitis prone children.
    Clin Exp Immunol. 1984 May;56(2):233-8 PMID: 6733969
  7. Tuberculosis, atypical mycobacteriosis, and the acquired immunodeficiency syndrome among Haitian and non-Haitian patients in south Florida.
    Ann Intern Med. 1984 Nov;101(5):641-5 PMID: 6333198
  8. Measurement of serum IgG4 levels by a competitive immunoenzymatic assay with monoclonal antibodies.
    J Immunol Methods. 1984 Nov 16;74(1):151-62 PMID: 6438233
  9. Serum immunoglobulin G subclass dysbalances in the lymphadenopathy syndrome and acquired immune deficiency syndrome.
    Clin Exp Immunol. 1986 Jan;63(1):234-40 PMID: 3955884
  10. Pneumococcal antibodies of different immunoglobulin subclasses in normal and IgG subclass deficient individuals of various ages.
    Acta Otolaryngol. 1986 Jan-Feb;101(1-2):146-51 PMID: 3962646
  11. Restricted IgG subclass responses to HTLV-III/LAV and to cytomegalovirus in patients with AIDS and lymphadenopathy syndrome.
    J Infect Dis. 1986 May;153(5):970-3 PMID: 3009638
  12. Localisation of the monocyte-binding region on human immunoglobulin G.
    Mol Immunol. 1986 Mar;23(3):319-30 PMID: 3487030
  13. Structure and antigenicity of the phosphorylated lipopolysaccharide antigens from the leprosy and tubercle bacilli.
    J Biol Chem. 1986 Sep 15;261(26):12345-51 PMID: 3091602
  14. Aspects of the molecular structure of IgG subclasses.
    Monogr Allergy. 1986;19:7-35 PMID: 2945094
  15. Tuberculosis in patients with the acquired immunodeficiency syndrome. Clinical features, response to therapy, and survival.
    Am Rev Respir Dis. 1987 Sep;136(3):570-4 PMID: 3631730
  16. Impaired anti-pneumococcal antibody response in patients with AIDS-related persistent generalized lymphadenopathy.
    Clin Exp Immunol. 1987 Jun;68(3):479-87 PMID: 3652522
  17. IgG subclasses to group B streptococci in normals, colonized woman and IgG2 subclass-deficient patients.
    Monogr Allergy. 1988;23:148-55 PMID: 3290659
  18. IgG subclass reactivity against human immunodeficiency virus (HIV) and cytomegalovirus in cerebrospinal fluid and serum from HIV-infected patients.
    J Med Virol. 1988 May;25(1):17-26 PMID: 2842444
  19. IgG subclass response to HIV in relation to antibody-dependent cellular cytotoxicity at different clinical stages.
    Clin Exp Immunol. 1988 Sep;73(3):343-7 PMID: 3208446
  20. Immunomodulatory role of IL-4 on the secretion of Ig by human B cells.
    J Immunol. 1989 Mar 1;142(5):1569-75 PMID: 2493049
  21. IgG subclasses of pneumococcal antibodies--effect of allotype G2m(n).
    Scand J Immunol. 1989 Feb;29(2):229-37 PMID: 2922573
  22. Immunoglobulin G subclass deficiency and susceptibility to pyogenic infections in patients with AIDS-related complex and AIDS.
    AIDS. 1989 Jan;3(1):37-9 PMID: 2496711
  23. Regulation of human B lymphocyte responsiveness.
    Scand J Rheumatol Suppl. 1988;76:229-35 PMID: 3075079
  24. Lipoarabinomannan from Mycobacterium tuberculosis induces the production of tumour necrosis factor from human and murine macrophages.
    Clin Exp Immunol. 1989 May;76(2):240-5 PMID: 2503277
  25. Prevalence of anti-group B streptococcal type III capsular IgG antibodies in the United Kingdom and an analysis of their specific IgG subclasses.
    J Infect Dis. 1990 Oct;162(4):883-7 PMID: 2205651
  26. Interleukin-4 induces both IgG4 and IgE secretion by peripheral blood B cells.
    J Clin Lab Anal. 1990;4(6):414-9 PMID: 2126556
  27. Natural infection of man with group A streptococci. Levels; restriction in class, subclass, and type; and clonal appearance of polysaccharide-group-specific antibodies.
    Scand J Immunol. 1976;5(4):383-90 PMID: 821139
Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
DOI
10.1111/j.1365-2249.1993.tb03348.x
Published
1993-01-00
Pages
25-9
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1554641
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1365-2249.1993.tb03348.x PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2