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PMID: 8414994 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

dHMG-Z, a second HMG-1-related protein in Drosophila melanogaster.

Nucleic acids research ·Vol. 21 ·No. 18 ·1993-09-11 ·Pages 4369-71

Ner SS, Churchill ME, Searles MA, Travers AA

Abstract

We report the identification of dHMG-Z, a gene related to dHMG-D and encoding a second invertebrate homologue of HMG 1 protein. The encoded proteins is 65% identical to dHMG-D protein, and also contains a single HMG-box as the DNA recognition motif. Analogous to dHMG-D, two transcripts are observed for dHMG-Z which are differentially regulated, and are the product of zygotic transcription unlike the dHMG-D transcripts which arise from both maternal and zygotic transcription. The genes for dHMG-D and dHMG-Z are located on adjacent loci in the genome and each contains two introns. The position of the second intron in the coding region is conserved between the two genes suggesting a common origin via gene duplication.

Related Genes
dHMG-D dHMG-Z
MeSH Terms
Animals Base Sequence Chromosome Mapping DNA Drosophila melanogaster/embryology,genetics,metabolism Female High Mobility Group Proteins/genetics Larva Male Molecular Sequence Data RNA, Messenger/metabolism
Chemicals
High Mobility Group Proteins RNA, Messenger DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Ner S S
MRC Laboratory of Molecular Biology, Cambridge, UK.
Churchill M E
Searles M A
Travers A A
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23 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/21.18.4369
Published
1993-09-11
Pages
4369-71
Language
English
Region
England
NLM ID
0411011
PMCID
PMC310074
Subset
IM
Databases
GENBANK
X71139
External Links
PubMed source DOI: 10.1093/nar/21.18.4369 PMC Full Text View journal details
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