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PMID: 8414901 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A two-step model of secretion control in neuroendocrine cells.

Pflugers Archiv : European journal of physiology ·Vol. 424 ·No. 2 ·1993-07-00 ·Pages 105-12

Heinemann C, von Rüden L, Chow RH, Neher E

Abstract

Recent experiments on a variety of neuroendocrine cells indicate that intense stimuli readily depress the secretory response. The most likely explanation for this depression is that a pool of release-ready granules is depleted. We present a two-step model of secretion that allows one to simulate the dynamics of such a pool for different time courses of free intracellular Ca concentration [Ca2+]i. We derive rate constants of the model from two types of experiment and find that, for the simplest type of model, not only the rate of consumption (exocytosis) but also the rate of vesicle supply to the pool of release-ready granules must be made Ca-dependent. Given these functional dependences a variety of results from the literature can be simulated. In particular, the model predicts the occurrence of secretory depression and augmentation under appropriate conditions.

MeSH Terms
Animals Caffeine/pharmacology Calcium/physiology Cattle Cells, Cultured Chromaffin System/cytology Exocytosis/physiology Kinetics Models, Biological Neurosecretion/physiology Neurosecretory Systems/cytology,physiology
Chemicals
Caffeine Calcium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Heinemann C
Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany.
von Rüden L
Chow R H
Neher E
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Article Info
Journal
Pflugers Archiv : European journal of physiology
Abbr.
Pflugers Arch
ISSN
0031-6768
DOI
10.1007/BF00374600
Published
1993-07-00
Pages
105-12
Language
English
Region
Germany
NLM ID
0154720
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00374600 View journal details
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