| GeneLibs

题目:: Evaluation of the utility of interphase cytogenetics to detect residual cells with a malignant genotype in mixed cell populations: a Burkitt lymphoma model.
作者:: Ried(T),Lengauer(C),Lipp(M),Fischer(C),Cremer(T),Ward(D C)
状态:: 发布时间1993-10-26 , 更新时间 2007-11-15
期刊:: DNA Cell Biol
摘要:: Interphase cytogenetics has been used to detect tumor cells in the presence of a large excess of normal cells. Probes for fluorescence in situ hybridization were chosen to reveal a specific hybridization pattern in tumor cell nuclei as well as to provide an internal control for the assessment of the hybridization results. By enumerating mixtures of cytogenetically normal cells and tumor cells from a Burkitt lymphoma cell line, we were able to detect tumor cells at a frequency of one in 500. Normal cells could be differentiated from Burkitt lymphoma cells with a specificity of approximately 99.9%.
语言:: eng
DOI:: 10.1089/dna.1993.12.637

文献库文献相关信息