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PMID: 8396264 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Chicken repeat 1 elements contain a pol-like open reading frame and belong to the non-long terminal repeat class of retrotransposons.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 90 ·No. 17 ·1993-09-01 ·Pages 8199-203

Burch JB, Davis DL, Haas NB

Abstract

Chicken genomes contain approximately 30,000 chicken repeat 1 (CR1) elements scattered among single-copy sequences, but no information has yet been presented to account for how these elements could have dispersed. The fact that CR1 elements have common (although atypical) 3' ends and variable 5' truncations suggested to us that they might belong to the class of non-long terminal repeat retrotransposons that encode reverse transcriptases. From an analysis of unusually large CR1 elements, we now provide evidence for the presence of such a reverse transcriptase open reading frame. CR1 elements are distantly related to previously described non-long terminal repeat retrotransposons; however, we find that frog and torpedo ray genomes contain dispersed open reading frame segments that have > 50% identity to the CR1 open reading frame. This result suggests that CR1-like elements exist in several vertebrate classes that have evolved independently for approximately 400 million years.

Related Genes
pol
MeSH Terms
Amino Acid Sequence Animals Base Sequence Chickens/genetics DNA/genetics,isolation & purification DNA Transposable Elements Genes, pol Genome Genomic Library Molecular Sequence Data Oligodeoxyribonucleotides Open Reading Frames Repetitive Sequences, Nucleic Acid Retroviridae/genetics Sequence Homology, Amino Acid
Chemicals
DNA Transposable Elements Oligodeoxyribonucleotides DNA
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Burch J B
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111.
Davis D L
Haas N B
References (29)
29 references, click to expand
  1. Organization and sequence analysis of a cluster of repetitive DNA elements from Xenopus laevis.
    J Mol Biol. 1981 Oct 5;151(4):573-92 PMID: 6173488
  2. Transcription and reverse transcription of retrotransposons.
    Annu Rev Microbiol. 1989;43:403-34 PMID: 2552899
  3. Structural analysis of a cDNA clone from Xenopus laevis containing a repetitive sequence element.
    Dev Biol. 1982 Nov;94(1):71-8 PMID: 6897540
  4. A retrotransposable element from the mosquito Anopheles gambiae .
    Mol Cell Biol. 1990 Mar;10(3):863-71 PMID: 1689457
  5. Single gene encodes glycophospholipid-anchored and asymmetric acetylcholinesterase forms: alternative coding exons contain inverted repeat sequences.
    Neuron. 1990 Feb;4(2):289-301 PMID: 2306366
  6. Origin and evolution of retroelements based upon their reverse transcriptase sequences.
    EMBO J. 1990 Oct;9(10):3353-62 PMID: 1698615
  7. Identification of a potential RNA intermediate for transposition of the LINE-like element I factor in Drosophila melanogaster.
    EMBO J. 1990 Nov;9(11):3557-63 PMID: 1698618
  8. Identification, characterization, and cell specificity of a human LINE-1 promoter.
    Mol Cell Biol. 1990 Dec;10(12):6718-29 PMID: 1701022
  9. Sequence conservation in avian CR1: an interspersed repetitive DNA family evolving under functional constraints.
    Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5814-8 PMID: 1829530
  10. Convergent transcription initiates from oppositely oriented promoters within the 5' end regions of Drosophila melanogaster F elements.
    Mol Cell Biol. 1991 Oct;11(10):5171-80 PMID: 1656225
  11. A de novo Alu insertion results in neurofibromatosis type 1.
    Nature. 1991 Oct 31;353(6347):864-6 PMID: 1719426
  12. Inactivation of the cholinesterase gene by Alu insertion: possible mechanism for human gene transposition.
    Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11315-9 PMID: 1662391
  13. Transposing without ends: the non-LTR retrotransposable elements.
    New Biol. 1992 May;4(5):430-40 PMID: 1325183
  14. Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition.
    Cell. 1993 Feb 26;72(4):595-605 PMID: 7679954
  15. Temporal order of chromatin structural changes associated with activation of the major chicken vitellogenin gene.
    Cell. 1983 May;33(1):65-76 PMID: 6088056
  16. Molecular cloning of a complementary DNA encoding human macrophage-specific colony-stimulating factor (CSF-1).
    Science. 1985 Oct 18;230(4723):291-6 PMID: 2996129
  17. Nonviral retroposons: genes, pseudogenes, and transposable elements generated by the reverse flow of genetic information.
    Annu Rev Biochem. 1986;55:631-61 PMID: 2427017
  18. Transposable elements controlling I-R hybrid dysgenesis in D. melanogaster are similar to mammalian LINEs.
    Cell. 1986 Dec 26;47(6):1007-15 PMID: 2430722
  19. Duplication of seven exons in LDL receptor gene caused by Alu-Alu recombination in a subject with familial hypercholesterolemia.
    Cell. 1987 Mar 13;48(5):827-35 PMID: 3815525
  20. Alu-Alu recombination deletes splice acceptor sites and produces secreted low density lipoprotein receptor in a subject with familial hypercholesterolemia.
    J Biol Chem. 1987 Mar 5;262(7):3354-61 PMID: 3818645
  21. Nucleotide sequence of a cDNA encoding murine CSF-1 (Macrophage-CSF).
    Nucleic Acids Res. 1987 Mar 11;15(5):2389-90 PMID: 3494232
  22. Organization, sequence and nuclease hypersensitivity of repetitive elements flanking the chicken apoVLDLII gene: extended sequence similarity to elements flanking the chicken vitellogenin gene.
    Nucleic Acids Res. 1988 Jan 11;16(1):97-113 PMID: 3340544
  23. Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man.
    Nature. 1988 Mar 10;332(6160):164-6 PMID: 2831458
  24. jockey, a mobile Drosophila element similar to mammalian LINEs, is transcribed from the internal promoter by RNA polymerase II.
    Cell. 1988 Aug 26;54(5):685-91 PMID: 2842063
  25. Complex alternative splicing of acetylcholinesterase transcripts in Torpedo electric organ; primary structure of the precursor of the glycolipid-anchored dimeric form.
    EMBO J. 1988 Oct;7(10):2983-93 PMID: 3181125
  26. Genetic applications of an inverse polymerase chain reaction.
    Genetics. 1988 Nov;120(3):621-3 PMID: 2852134
  27. Reverse transcriptases. Retrons in bacteria.
    Nature. 1989 May 25;339(6222):254-5 PMID: 2471077
  28. Evidence that chicken CR1 elements represent a novel family of retroposons.
    Mol Cell Biol. 1989 Aug;9(8):3563-6 PMID: 2477689
  29. SINEs and LINEs: highly repeated short and long interspersed sequences in mammalian genomes.
    Cell. 1982 Mar;28(3):433-4 PMID: 6280868
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.90.17.8199
Published
1993-09-01
Pages
8199-203
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC47316
Subset
IM
Grants
PHS HHS · 35535 · United States
NCI NIH HHS · CA-06927 · United States
Databases
GENBANK
L22146, L22147, L22148, L22149, L22150, L22151, L22152, L22153, M11296, M24187, M35464, V01437, X13173, X56517
External Links
PubMed source DOI: 10.1073/pnas.90.17.8199 PMC Full Text View journal details
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