Abstract
Eight patients affected by non-small-cell lung cancer were treated with intralesional and systemic recombinant IL-2 (rIL-2) injection with the aim of activating both tumour-infiltrating lymphocytes and circulating cytotoxic or killer cells. The schedule of treatment was as follows: a daily fine-needle transparietal intralesional rIL-2 injection (1 x 10(5) Cetus units) from day 1 to day 5 and systemic rIL-2 infusion (1 x 10(5) Cetus units kg-1 day-1) from day 6 to day 10. One to four cycles of treatment were received by each patient. Clinical and immunological evaluations were performed (a) before treatment, (b) following the intralesional rIL-2 administration, (c) 1 h after the beginning of rIL-2 infusion and (d) at the end of the systemic rIL-2 infusion. No complete remission was achieved, two patients showed a partial remission, three resulted in stable disease and three patients progressed. Natural killer and lymphokine-activated killer cell activity dramatically decreased 1 h after the beginning of rIL-2 infusion and increased at the end of treatment. A progressive increase of circulating CD8+ and HLA class II+ T cells as well as of CD8+ T cell clones, most of which displayed NK activity, was recorded following rIL-2 infusion. Present data indicate that (a) the local administration of rIL-2 coupled with systemic rIL-2 infusion may be suggested as an alternative approach for the immunotherapy of lung cancer, (b) rIL-2 induces different immunological modifications according to the route and the time of its administration and (c) rIL-2 administration increases the amount of circulating immune cells with potential antitumour activity.
MeSH Terms
Carcinoma, Non-Small-Cell Lung/immunology,therapy
Cytotoxicity Tests, Immunologic
Humans
Immunophenotyping
Immunotherapy
Interleukin-2/administration & dosage,therapeutic use
Killer Cells, Lymphokine-Activated/immunology
Killer Cells, Natural/immunology
Lung Neoplasms/immunology,therapy
Male
Middle Aged
Pilot Projects
Recombinant Proteins/therapeutic use
Chemicals
Interleukin-2
Recombinant Proteins
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Scudeletti M
Department of Internal Medicine, University of Genoa, Italy.
Filaci G
Imro M A
Motta G
Di Gaetano M
Pierri I
Tongiani S
Indiveri F
Puppo F
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