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PMID: 8389217 Published · ppublish English Comparative Study Journal Article Review

Skeletal myogenesis: genetics and embryology to the fore.

Current opinion in genetics & development ·Vol. 3 ·No. 2 ·1993-04-00 ·Pages 265-74

Emerson CP

Abstract

The MyoD family of transcription factors are expressed in the skeletal muscles of vertebrate and invertebrate embryos and have dominant regulatory activities that indicate their important developmental functions in myogenic lineage determination and muscle differentiation. Genetic studies, however, reveal that individually, myoD-related genes are not essential for myogenic lineage determination in mouse and Caenorhabditis elegans embryos, but have differentiation functions and perhaps redundant functions in lineage determination that remain to be defined by further genetic studies.

Related Genes
CMD1 CMRF4 MEF2 MRF4 Mhox Qmyf5 QmyoD SUM1 XMRF4 XMyf5 XMyoD fos hlh1 jun myf3 myf4 myf5 myf6 myoD nau qmf1 qmf2 qmf3
MeSH Terms
Amino Acid Sequence Animals Cell Differentiation DNA-Binding Proteins Embryonic and Fetal Development/genetics Humans Invertebrates/embryology,genetics Molecular Sequence Data Morphogenesis/genetics Multigene Family Muscle Proteins/genetics,physiology Muscles/embryology MyoD Protein Myogenic Regulatory Factor 5 Myogenic Regulatory Factors Myogenin Nuclear Proteins/genetics,physiology Phosphoproteins/genetics,physiology Trans-Activators Transcription Factors/genetics,physiology Vertebrates/embryology,genetics
Chemicals
DNA-Binding Proteins MYF5 protein, human MYOG protein, human Muscle Proteins MyoD Protein MyoD1 myogenic differentiation protein Myogenic Regulatory Factor 5 Myogenic Regulatory Factors Myogenin Nuclear Proteins Phosphoproteins Trans-Activators Transcription Factors myogenic factor 6
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Emerson C P
Institute for Cancer Research, Fox Chase Cancer Center, PA 19111.
Article Info
Journal
Current opinion in genetics & development
Abbr.
Curr Opin Genet Dev
ISSN
0959-437X
DOI
10.1016/0959-437x(93)90033-l
Published
1993-04-00
Pages
265-74
Language
English
Region
England
NLM ID
9111375
Subset
IM
External Links
PubMed source DOI: 10.1016/0959-437x(93)90033-l View journal details
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