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PMID: 8384116 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent.

European journal of pharmacology ·Vol. 231 ·No. 2 ·1993-02-09 ·Pages 313-4

Fride E, Mechoulam R

Abstract

Anandamide (arachidonylethanolamide) is a brain constituent which binds to the cannabinoid receptor. We now report the first in vivo examination of this ligand. Anandamide administered i.p. in mice, caused lowering of activity in an immobility and in an open field test, and produced hypothermia and analgesia. These effects parallel those caused by psychotropic cannabinoids.

MeSH Terms

Amides/pharmacology Animals Arachidonic Acids Behavior, Animal/drug effects Body Temperature/drug effects Brain Chemistry/physiology Dronabinol/pharmacology Endocannabinoids Fatty Acids, Unsaturated/pharmacology Female Injections, Intraperitoneal Male Mice Mice, Inbred C57BL Motor Activity/drug effects Polyunsaturated Alkamides Receptors, Cannabinoid Receptors, Drug/drug effects Stimulation, Chemical

Chemicals

Amides Arachidonic Acids Endocannabinoids Fatty Acids, Unsaturated Polyunsaturated Alkamides Receptors, Cannabinoid Receptors, Drug Dronabinol anandamide

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Fride E

Department of Natural Products, Hebrew University, Pharmacy School, Jerusalem, Israel.

Mechoulam R

Article Info

Journal

European journal of pharmacology

Abbr.

Eur J Pharmacol

ISSN

0014-2999

DOI

10.1016/0014-2999(93)90468-w

Published

1993-02-09

Pages

313-4

Language

English

Region

Netherlands

NLM ID

1254354

Subset

External Links

PubMed source DOI: 10.1016/0014-2999(93)90468-w View journal details

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Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent.

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