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PMID: 8356450 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Identification of a structural glycoprotein of an RNA virus as a ribonuclease.

Science (New York, N.Y.) ·Vol. 261 ·No. 5125 ·1993-08-27 ·Pages 1169-71

Schneider R, Unger G, Stark R, Schneider-Scherzer E, Thiel HJ

Abstract

One of the three structural glycoproteins of classical swine fever virus (CSFV) is E0, a disulfide-bonded homodimer that induces virus-neutralizing antibodies and occurs in a virion-bound as well as a secreted form. E0 was shown to be similar to a family of fungal and plant ribonucleases. Purified E0 from CSFV-infected cells was a potent ribonuclease specific for uridine and inhibitable by zinc ions.

MeSH Terms

Amino Acid Sequence Classical Swine Fever Virus/chemistry,enzymology,genetics Dithiothreitol/pharmacology Hydrogen-Ion Concentration Molecular Sequence Data Oxidation-Reduction RNA, Fungal/metabolism Ribonucleases/chemistry,isolation & purification,metabolism Sequence Analysis Single-Chain Antibodies Substrate Specificity Temperature Uridine/metabolism Viral Structural Proteins/chemistry,isolation & purification,metabolism

Chemicals

RNA, Fungal Single-Chain Antibodies Viral Structural Proteins glycoprotein EO, classical swine fever virus Ribonucleases Dithiothreitol Uridine

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Schneider R

Department of Biochemistry, Faculty of Natural Sciences, University of Innsbruck, Austria.

Unger G

Stark R

Schneider-Scherzer E

Thiel H J

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.8356450

Published

1993-08-27

Pages

1169-71

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.8356450 View journal details

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Identification of a structural glycoprotein of an RNA virus as a ribonuclease.

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