Accelerated ageing or selective neuronal loss as an important cause of dementia?

Lancet (London, England) ·Vol. 1 ·No. 8106 ·1979-01-06 ·Pages 11-4

Bowen DM, White P, Spillane JA, Goodhardt MJ, Curzon G, Iwangoff P, Meier-Ruge W, Davison AN

Abstract

Extensive biochemical analysis of whole temporal lobe from cases of dementia and controls suggests that Alzheimer's disease is a primary degenerative nerve-cell disorder and not the result of accelerated ageing. There is selective loss of neocortical cholinergic neurones. Transmitter systems apart from the cholinergic system appears to be affected, but to a lesser extent, and there are no significant changes in the caudate nucleus. The change in cholinergic neurones has been confirmed in biopsy samples.

MeSH Terms

Aged Aging Alzheimer Disease/etiology,metabolism,pathology Atrophy Caudate Nucleus/pathology Cell Count Choline O-Acetyltransferase/deficiency Dementia/etiology Female Fructose-Bisphosphate Aldolase/deficiency Glycolysis Humans Hydroxyindoleacetic Acid/deficiency Male Middle Aged Nerve Degeneration Phosphofructokinase-1/deficiency Receptors, Cholinergic Serotonin/deficiency Temporal Lobe/metabolism,pathology

Chemicals

Receptors, Cholinergic Serotonin Hydroxyindoleacetic Acid Choline O-Acetyltransferase Phosphofructokinase-1 Fructose-Bisphosphate Aldolase

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Bowen D M

White P

Spillane J A

Goodhardt M J

Curzon G

Iwangoff P

Meier-Ruge W

Davison A N

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(79)90454-9

Published

1979-01-06

Pages

11-4

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(79)90454-9 View journal details

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