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PMID: 8342595 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain.

The American journal of pathology ·Vol. 143 ·No. 2 ·1993-08-00 ·Pages 446-52

Schmied M, Breitschopf H, Gold R, Zischler H, Rothe G, Wekerle H, Lassmann H

Abstract

In experimental autoimmune encephalomyelitis (EAE) myelin-specific T lymphocytes attack the myelinated tissue of the central nervous system (CNS). In the Lewis rat, EAE as a rule has an acute, monophasic course. With spontaneous clinical recovery the inflammatory CNS infiltrates are cleared from the nervous tissue within a few days. This is well in line with the remarkably low incidence of myelin-specific T cells present in EAE infiltrate. Combining immunocytochemical techniques, ultrastructural criteria and in situ nick translation we found up to 49% of T lymphocytes in EAE lesions showing signs of apoptosis at the time of recovery from disease. Our results suggest that apoptosis of T lymphocytes may be one possible mechanism to eliminate T lymphocytes from inflammatory brain lesions.

MeSH Terms
Animals Apoptosis Brain/ultrastructure Cell Death DNA Damage Encephalomyelitis, Autoimmune, Experimental/pathology,physiopathology Genetic Techniques Immunoenzyme Techniques Leukocyte Count Rats Rats, Inbred Lew Rats, Sprague-Dawley T-Lymphocytes/ultrastructure
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Schmied M
Research Unit of Experimental Neuropathology, Austrian Academy of Sciences, Vienna.
Breitschopf H
Gold R
Zischler H
Rothe G
Wekerle H
Lassmann H
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1993-08-00
Pages
446-52
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1887018
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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