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PMID: 8301408 Published · ppublish English Comparative Study Journal Article Review

Photochemical interactions of methylene blue and analogues with DNA and other biological substrates.

Journal of photochemistry and photobiology. B, Biology ·Vol. 21 ·No. 2-3 ·1993-12-00 ·Pages 103-24

Tuite EM, Kelly JM

Abstract

The light-induced reactions of methylene blue and related phenothiazinium dyes with biological substrates are described. The properties of the excited states of the dyes, their reactions with nucleic acids and their photosensitised chemical modifications of nucleic acid bases are examined. Reports on phenothiazinium dye-induced damage to proteins, lipids, biological membranes, organelles, viruses, bacteria, mammalian cells and carcinomas are reviewed.

MeSH Terms

Animals Bacteria/drug effects Cell Line DNA/chemistry Eukaryotic Cells/drug effects Humans Lipids/chemistry Mammals Membrane Lipids/chemistry Methylene Blue/analogs & derivatives,chemistry,pharmacology Neoplasms/drug therapy Nucleotides/chemistry Organelles/drug effects Photochemistry Photochemotherapy Polynucleotides/chemistry Proteins/chemistry Tumor Cells, Cultured Viruses/drug effects

Chemicals

Lipids Membrane Lipids Nucleotides Polynucleotides Proteins DNA Methylene Blue

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Tuite E M

Chemistry Department, Trinity College, Dublin, Ireland.

Kelly J M

Article Info

Journal

Journal of photochemistry and photobiology. B, Biology

Abbr.

J Photochem Photobiol B

ISSN

1011-1344

DOI

10.1016/1011-1344(93)80173-7

Published

1993-12-00

Pages

103-24

Language

English

Region

Switzerland

NLM ID

8804966

Subset

External Links

PubMed source DOI: 10.1016/1011-1344(93)80173-7 View journal details

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Photochemical interactions of methylene blue and analogues with DNA and other biological substrates.

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