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PMID: 83000 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

N-acetyl gramicidin: single-channel properties and implications for channel structure.

Science (New York, N.Y.) ·Vol. 203 ·No. 4375 ·1979-01-05 ·Pages 55-7

Szabo G, Urry DW

Abstract

Substitution of a methyl group for the N-terminal hydrogen of gramicidin greatly increased the rate of dissociation of conductive channels in lipid bilayer membranes. The finding of short lifetimes for conductive channels, comparable to those seen for the neuromuscular junction, lends support to the head-to-head dimer structure for the conductive channel.

MeSH Terms

Cations, Monovalent Electric Conductivity Gramicidin Ion Channels Membranes, Artificial Models, Biological Structure-Activity Relationship

Chemicals

Cations, Monovalent Ion Channels Membranes, Artificial Gramicidin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Szabo G

Urry D W

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.83000

Published

1979-01-05

Pages

55-7

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.83000 View journal details

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N-acetyl gramicidin: single-channel properties and implications for channel structure.

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