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题目:: Function of a human cyclin gene as an oncogene.
作者:: Hinds(P W),Dowdy(S F),Eaton(E N),Arnold(A),Weinberg(R A)
状态:: 发布时间1994-02-22 , 更新时间 2016-10-19
期刊:: Proc Natl Acad Sci U S A
摘要:: The cyclin D1 (PRAD1, CCND1) gene is affected by translocations and amplification in the genomes of a number of human tumors, suggesting that these changes confer growth advantage on developing tumor cell clones. We show here that in cultured cells, a cDNA clone of the cyclin D1 gene can contribute to cell transformation by complementing a defective adenovirus E1A oncogene. In such cells, this candidate oncogene indeed functions like an oncogene, suggesting a similar role in tumor progression in vivo.
语言:: eng
DOI:

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