Effect of myo-inositol on peripheral-nerve function in diabetes.

Lancet (London, England) ·Vol. 2 ·No. 8103 ·1978-12-16 ·Pages 1282-4

Salway JG, Whitehead L, Finnegan JA, Karunanayaka A, Barnett D, Payne RB

Abstract

myo-Inositol, 500 mg twice a day, given to seven diabetic patients for two weeks, increased the amplitude of the evoked action potentials of the median, sural, and popliteal nerves by an average of 76%, 160%, and 40%, respectively. There was no significant change in the conduction velocities of these nerves, myo-Inositol may be valuable in the treatment of diabetic neuropathy.

MeSH Terms

Aged Clinical Trials as Topic Diabetes Mellitus/physiopathology Diabetic Neuropathies/drug therapy Dose-Response Relationship, Drug Double-Blind Method Drug Evaluation Evoked Potentials/drug effects Humans Inositol/administration & dosage,pharmacology,therapeutic use Lumbosacral Plexus/physiopathology Median Nerve/physiopathology Middle Aged Neural Conduction/drug effects Peripheral Nerves/drug effects,physiopathology Placebos Sural Nerve/physiopathology

Chemicals

Placebos Inositol

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Salway J G

Whitehead L

Finnegan J A

Karunanayaka A

Barnett D

Payne R B

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(78)92043-3

Published

1978-12-16

Pages

1282-4

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(78)92043-3 View journal details

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