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PMID: 8278397 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Mode of cell proliferation in the developing mouse neocortex.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 1 ·1994-01-04 ·Pages 375-9

Takahashi T, Nowakowski RS, Caviness VS

Abstract

There are two proliferative populations in the developing cerebral wall: the pseudostratified ventricular epithelium (PVE) and the secondary proliferative population (SPP). The present experiments provide on embryonic day 14 (E14) in the mouse direct measures of the values for the proportions of daughter cells that continue to proliferate (proliferative, P fraction, or P) and for those that leave the cell cycle (quiescent, Q fraction, or Q; Q = 1 - P) for both of these populations. The range of values of P for the PVE, 0.62-0.66, would provide for the relatively low rate of neuronal output and for an expansion of the proliferative population appropriate for E14. The even higher values of P for the SPP, 0.73-1.0, would expand this population rapidly in preparation for the high glial cell output to occur later in cerebral histogenesis.

MeSH Terms

Animals Brain/cytology,embryology Cell Division Epithelial Cells Mice Mice, Inbred Strains Neuroglia/cytology Neurons/cytology

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Takahashi T

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston 02114.

Nowakowski R S

Caviness V S

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.91.1.375

Published

1994-01-04

Pages

375-9

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC42950

Subset

Grants

NINDS NIH HHS · NS12005 · United States

NINDS NIH HHS · NS28061 · United States

External Links

PubMed source DOI: 10.1073/pnas.91.1.375 PMC Full Text View journal details

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Mode of cell proliferation in the developing mouse neocortex.

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