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PMID: 8276641 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Fibres of intermediate type 1C and 2C are found continuously in mdx soleus muscle up to 52 weeks.

Histochemistry ·Vol. 100 ·No. 4 ·1993-10-00 ·Pages 271-6

Pastoret C, Sebille A

Abstract

The mdx mutant is a murine homologous model of Duchenne muscular dystrophy (DMD). Fibre types determined by the myosin-ATPase technique in soleus muscles were compared in C57BL/10 control and mdx mice from 3 to 52 weeks of age. The control strain continuously presented 70% of type 2 fibres whereas the mdx strain showed an increase to 80% at 6 weeks and a subsequent decline. In mdx muscles, necrosis which begins at 3 weeks of age did not affect specifically one type of fibre. Type grouping was never observed when muscle regeneration occurred. Fibres of intermediate type (1C and 2C) were found continuously up to 52 weeks of age in the mdx mutant. The foci of small immature regenerating fibres were of type 2C but never 1C. A few mature fibres were either of type 2C or 1C. We suggest that the presence of intermediate type fibres could result from the co-expression of type 1 and 2 myosin heavy chains, indicating a transition from type 2 to type 1 in regenerating fibres.

MeSH Terms
Animals Male Mice Mice, Inbred C57BL Mice, Mutant Strains Muscle Development Muscles/pathology,physiology Muscular Dystrophy, Animal/pathology Myosins/immunology,metabolism Regeneration
Chemicals
Myosins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pastoret C
Laboratoire de Physiologie, Atelier de Régénération Neuromusculaire, Faculté de Médecine Saint-Antoine, Paris, France.
Sebille A
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Article Info
Journal
Histochemistry
Abbr.
Histochemistry
ISSN
0301-5564
DOI
10.1007/BF00270046
Published
1993-10-00
Pages
271-6
Language
English
Region
Germany
NLM ID
0411300
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00270046
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