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题目:: Expression of sialyl-Tn antigen is correlated with survival time of patients with gastric carcinomas.
作者:: Ma(X C),Terata(N),Kodama(M),Jancic(S),Hosokawa(Y),Hattori(T)
状态:: 发布时间1994-01-25 , 更新时间 2015-11-19
期刊:: Eur J Cancer
摘要:: Expression of sialyl-Tn antigen (STN) was examined by an immunohistochemical method in 85 primary gastric carcinomas. The STN expression occurred in 53 (62.4%) cancers, and the positive staining was correlated with degree of gastric wall and lymph vessel invasion, lymph node metastasis, and stage of tumour. Five-year survival rates of patients with STN-positive cancers (47.2%) were significantly lower than those with STN-negative cancers (84.4%) (P < 0.01), and patients with STN-positive cancers at stage III and stage IV had a worse prognosis. In the cancers with serosal invasion, patients with STN-positive cancer disclosed a significantly poorer prognosis than those with STN-negative cancers (P < 0.01). Therefore, it is suggested that a careful follow-up study and intensive postoperative therapy are needed for patients with advanced gastric cancers with positive STN expression.
语言:: eng
DOI:

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