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PMID: 8256853 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Immunohistochemical localization of advanced glycosylation end products in coronary atheroma and cardiac tissue in diabetes mellitus.

The American journal of pathology ·Vol. 143 ·No. 6 ·1993-12-00 ·Pages 1649-56

Nakamura Y, Horii Y, Nishino T, Shiiki H, Sakaguchi Y, Kagoshima T, Dohi K, Makita Z, Vlassara H, Bucala R

Abstract

Advanced glycosylation end products (AGEs) accumulate on long-lived extracellular matrix proteins and have been implicated in the micro- and macrovascular complications of diabetes mellitus. Within the arterial wall, AGE-modified proteins increase vascular permeability, inactivate nitric oxide activity, and induce the release of growth-promoting cytokines. Recently developed anti-AGE antibodies were used in an immunohistochemical analysis of coronary arteries obtained from type II diabetic and nondiabetic patients. High levels of AGE reactivity were observed within the atherosclerotic plaque present in vessels from selected patients with diabetes. Considered together with the pathological effects of AGEs on vascular wall homeostasis, these data support the role of advanced glycosylation in the rapidly progressive atherosclerosis associated with diabetes mellitus.

MeSH Terms
Aged Aged, 80 and over Arteries/chemistry,metabolism,pathology Coronary Artery Disease/metabolism,pathology Coronary Vessels/chemistry,metabolism,pathology Cytoplasmic Granules/chemistry,ultrastructure Diabetes Mellitus, Type 2/metabolism,pathology Diabetic Angiopathies/metabolism,pathology Female Glycation End Products, Advanced/analysis,metabolism Glycosylation Humans Immunohistochemistry Male Middle Aged
Chemicals
Glycation End Products, Advanced
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Nakamura Y
First Department of Internal Medicine, Nara Medical University, Japan.
Horii Y
Nishino T
Shiiki H
Sakaguchi Y
Kagoshima T
Dohi K
Makita Z
Vlassara H
Bucala R
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1993-12-00
Pages
1649-56
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1887270
Subset
IM
Grants
NIA NIH HHS · AG-9453 · United States
External Links
PubMed source PMC Full Text View journal details
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