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PMID: 8254755 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Mapping the Flv locus controlling resistance to flaviviruses on mouse chromosome 5.

Journal of virology ·Vol. 68 ·No. 1 ·1994-01-00 ·Pages 448-52

Sangster MY, Urosevic N, Mansfield JP, Mackenzie JS, Shellam GR

Abstract

Genetically determined resistance to flaviviruses in mice is a dominant trait conferred by alleles at a single autosomal locus designated Flv, but no gene products have been associated with this locus and the mechanism of resistance is not well understood. To further characterize this model of genetic resistance, we conducted mapping studies to determine the chromosomal location of Flv. Because of evidence suggesting that the Flv locus is on chromosome 5, three-point backcross linkage analyses were used to define the location of Flv relative to previously assigned chromosome 5 markers. The results confirm the chromosome 5 location of Flv and indicate a map position between the anchor loci rd and Gus-s. The chromosomal localization of Flv is the first step in the production of a detailed linkage map of the Flv region, which may open approaches to positional cloning of the resistance gene.

Related Genes
flv
MeSH Terms
Animals Chromosome Mapping Crosses, Genetic Flavivirus Infections/genetics,immunology,microbiology Genetic Linkage Genetic Markers Immunity, Innate/genetics Mice Mice, Inbred BALB C/genetics Mice, Inbred C3H/genetics Mice, Inbred Strains/genetics Recombination, Genetic Virulence
Chemicals
Genetic Markers
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Sangster M Y
Department of Microbiology, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands.
Urosevic N
Mansfield J P
Mackenzie J S
Shellam G R
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.68.1.448-452.1994
Published
1994-01-00
Pages
448-52
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC236305
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.68.1.448-452.1994 PMC Full Text View journal details
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