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PMID: 8240230 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The glucose transporter family: structure, function and tissue-specific expression.

The Biochemical journal ·Vol. 295 ( Pt 2) ·1993-10-15 ·Pages 329-41

Gould GW, Holman GD

Abstract

暂无摘要

MeSH Terms
Amino Acid Sequence Animals Diabetes Mellitus/metabolism Humans Insulin/physiology Molecular Sequence Data Monosaccharide Transport Proteins/chemistry,metabolism
Chemicals
Insulin Monosaccharide Transport Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gould G W
Department of Biochemistry, University of Glasgow, Scotland, U.K.
Holman G D
References (140)
140 references, click to expand
  1. Investigation of the structure and function of the human erythrocyte glucose transporter by proteolytic dissection.
    Biochim Biophys Acta. 1987 Dec 11;905(2):295-310 PMID: 3689782
  2. The yeast SNF3 gene encodes a glucose transporter homologous to the mammalian protein.
    Proc Natl Acad Sci U S A. 1988 Apr;85(7):2130-4 PMID: 3281163
  3. Characterization and expression of human HepG2/erythrocyte glucose-transporter gene.
    Diabetes. 1988 May;37(5):657-61 PMID: 2834252
  4. Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus.
    J Clin Invest. 1988 May;81(5):1528-36 PMID: 3366906
  5. The cloning, DNA sequence, and overexpression of the gene araE coding for arabinose-proton symport in Escherichia coli K12.
    J Biol Chem. 1988 Jun 15;263(17):8003-10 PMID: 2836407
  6. Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein.
    Proc Natl Acad Sci U S A. 1988 Aug;85(15):5434-8 PMID: 3399500
  7. An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects.
    J Clin Invest. 1988 Aug;82(2):486-94 PMID: 3403714
  8. Growth factors rapidly induce expression of the glucose transporter gene.
    J Biol Chem. 1988 Sep 25;263(27):13655-62 PMID: 3262104
  9. Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells.
    Cell. 1988 Oct 21;55(2):281-90 PMID: 3048704
  10. Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues.
    J Biol Chem. 1988 Oct 25;263(30):15245-8 PMID: 3170580
  11. Insulin-induced translocation of glucose transporters to the plasma membrane precedes full stimulation of hexose transport.
    Biochemistry. 1988 Sep 6;27(18):6681-5 PMID: 3058203
  12. The rat facilitated glucose transporter gene. Transformation and serum-stimulated transcription initiate from identical sites.
    J Biol Chem. 1988 Dec 25;263(36):19513-8 PMID: 3198639
  13. Determination of the rates of appearance and loss of glucose transporters at the cell surface of rat adipose cells.
    Biochem J. 1991 Aug 15;278 ( Pt 1):235-41 PMID: 1883332
  14. Metformin increases insulin-stimulated glucose transport in insulin-resistant human skeletal muscle.
    Diabete Metab. 1991 May;17(1 Pt 2):159-63 PMID: 1936469
  15. Evidence that functional erythrocyte-type glucose transporters are oligomers.
    J Biol Chem. 1991 Oct 25;266(30):20213-7 PMID: 1939082
  16. Effect of denervation on the expression of two glucose transporter isoforms in rat hindlimb muscle.
    J Clin Invest. 1991 Nov;88(5):1546-52 PMID: 1939643
  17. Glucose transporter expression in brain. cDNA sequence of mouse GLUT3, the brain facilitative glucose transporter isoform, and identification of sites of expression by in situ hybridization.
    J Biol Chem. 1992 Jan 5;267(1):467-72 PMID: 1730609
  18. Isoform-specific subcellular targeting of glucose transporters in mouse fibroblasts.
    J Cell Biol. 1992 Feb;116(3):785-97 PMID: 1309819
  19. Regulation of the functional expression of hexose transporter GLUT-1 by glucose in murine fibroblasts: role of lysosomal degradation.
    Biochemistry. 1992 Jun 16;31(23):5386-93 PMID: 1606164
  20. Translocation of the glucose transporter (GLUT4) to the cell surface in permeabilized 3T3-L1 adipocytes: effects of ATP insulin, and GTP gamma S and localization of GLUT4 to clathrin lattices.
    J Cell Biol. 1992 Jun;117(6):1181-96 PMID: 1607382
  21. A potential hexose transporter gene expressed predominantly in the bloodstream form of Trypanosoma brucei.
    Mol Biochem Parasitol. 1992 May;52(1):111-21 PMID: 1625698
  22. Subcellular distribution and activity of glucose transporter isoforms GLUT1 and GLUT4 transiently expressed in COS-7 cells.
    Biochim Biophys Acta. 1992 Jul 15;1131(3):245-52 PMID: 1627641
  23. [Val12] HRAS downregulates GLUT2 in beta cells of transgenic mice without affecting glucose homeostasis.
    Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5744-8 PMID: 1631055
  24. Fructose transporter in human spermatozoa and small intestine is GLUT5.
    J Biol Chem. 1992 Jul 25;267(21):14523-6 PMID: 1634504
  25. Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells.
    Endocrinology. 1992 Sep;131(3):1165-73 PMID: 1505458
  26. Expression of the brain-type glucose transporter is restricted to brain and neuronal cells in mice.
    Diabetologia. 1992 Apr;35(4):304-9 PMID: 1516757
  27. Site-directed mutagenesis of GLUT1 in helix 7 residue 282 results in perturbation of exofacial ligand binding.
    J Biol Chem. 1992 Sep 5;267(25):17502-7 PMID: 1517202
  28. Effects of insulin on steady state kinetics of GLUT4 subcellular distribution in rat adipocytes. Evidence of constitutive GLUT4 recycling.
    J Biol Chem. 1992 Sep 5;267(25):17710-5 PMID: 1517217
  29. Cloning and expression of a hepatic microsomal glucose transport protein. Comparison with liver plasma-membrane glucose-transport protein GLUT 2.
    Biochem J. 1992 Aug 15;286 ( Pt 1):173-7 PMID: 1520266
  30. Replacement of intracellular C-terminal domain of GLUT1 glucose transporter with that of GLUT2 increases Vmax and Km of transport activity.
    J Biol Chem. 1992 Nov 5;267(31):22550-5 PMID: 1429604
  31. Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes.
    Proc Natl Acad Sci U S A. 1989 May;86(9):3150-4 PMID: 2654938
  32. Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues.
    J Biol Chem. 1989 May 15;264(14):7776-9 PMID: 2656669
  33. Recovery of maximal insulin responsiveness and insulin sensitivity after induction of insulin resistance in primary cultured adipocytes.
    J Biol Chem. 1989 May 15;264(14):8156-63 PMID: 2656674
  34. DNA sequence, organization and regulation of the qa gene cluster of Neurospora crassa.
    J Mol Biol. 1989 May 5;207(1):15-34 PMID: 2525625
  35. Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting.
    Nature. 1989 Jul 6;340(6228):70-2 PMID: 2739728
  36. Regulation of glucose transporter messenger RNA in insulin-deficient states.
    Nature. 1989 Jul 6;340(6228):72-4 PMID: 2662016
  37. Insulin-regulated glucose uptake in rat adipocytes is mediated by two transporter isoforms present in at least two vesicle populations.
    J Biol Chem. 1989 Jul 25;264(21):12358-63 PMID: 2545707
  38. Subcellular distribution of GLUT 4 in the skeletal muscle of lean type 2 (non-insulin-dependent) diabetic patients in the basal state.
    Diabetologia. 1992 May;35(5):456-63 PMID: 1325931
  39. Domains responsible for the differential targeting of glucose transporter isoforms.
    J Biol Chem. 1992 Sep 25;267(27):19636-41 PMID: 1527083
  40. Human small intestine facilitative fructose/glucose transporter (GLUT5) is also present in insulin-responsive tissues and brain. Investigation of biochemical characteristics and translocation.
    Diabetes. 1992 Oct;41(10):1360-5 PMID: 1397712
  41. The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi.
    J Cell Biol. 1992 Oct;119(2):249-57 PMID: 1400571
  42. Insulin resistance in obese Zucker rat (fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation.
    J Clin Invest. 1992 Oct;90(4):1568-75 PMID: 1401086
  43. Distribution of GLUT3 glucose transporter protein in human tissues.
    Biochem Biophys Res Commun. 1992 Oct 15;188(1):149-54 PMID: 1417839
  44. Mammalian facilitative glucose transporters: evidence for similar substrate recognition sites in functionally monomeric proteins.
    Biochemistry. 1992 Oct 27;31(42):10414-20 PMID: 1420159
  45. Islet-cell-surface antibodies in juvenile diabetes mellitus.
    N Engl J Med. 1978 Aug 24;299(8):375-80 PMID: 353557
  46. Kinetic parameters of transport of 3-O-methylglucose and glucose in adipocytes.
    J Biol Chem. 1979 Jun 25;254(12):5276-83 PMID: 447648
  47. Kinetics of 3-O-methyl-D-glucose transport in isolated rat hepatocytes.
    Biochem J. 1979 Aug 15;182(2):503-8 PMID: 508295
  48. Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane.
    J Biol Chem. 1980 May 25;255(10):4758-62 PMID: 6989818
  49. Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site.
    Proc Natl Acad Sci U S A. 1980 May;77(5):2542-5 PMID: 6771756
  50. The monosaccharide transporter of the human erythrocyte. Transport activity upon reconstitution.
    J Biol Chem. 1981 Apr 25;256(8):3685-9 PMID: 7194337
  51. Insulin-stimulated translocation of glucose transport systems in the isolated rat adipose cell. Time course, reversal, insulin concentration dependency, and relationship to glucose transport activity.
    J Biol Chem. 1981 May 25;256(10):4772-7 PMID: 7014557
  52. Hexose transport in human adipocytes: factors influencing the response to insulin and kinetics of methylglucose and glucose transport.
    Diabetologia. 1981 Jun;20(6):630-5 PMID: 7021279
  53. Symmetrical kinetic parameters for 3-O-methyl-D-glucose transport in adipocytes in the presence and in the absence of insulin.
    Biochim Biophys Acta. 1981 Apr 6;642(2):325-35 PMID: 7025902
  54. Sugar transport across the hepatocyte plasma membrane.
    Biochem Soc Trans. 1982 Feb;10(1):12-3 PMID: 7199490
  55. Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins.
    Nature. 1982 Jul 8;298(5870):167-9 PMID: 7045690
  56. The simple model of adipocyte hexose transport. Kinetic features, effect of insulin, and network thermodynamic computer simulations.
    J Biol Chem. 1982 Oct 10;257(19):11601-8 PMID: 6749843
  57. Monosaccharide transporter of the human erythrocyte. Characterization of an improved preparation.
    Biochemistry. 1982 Aug 3;21(16):3836-42 PMID: 6890381
  58. Identification of the D-glucose-inhibitable cytochalasin B binding site as the glucose transporter in rat diaphragm plasma and microsomal membranes.
    Biochim Biophys Acta. 1983 Apr 21;730(1):49-56 PMID: 6338925
  59. Unique cytochalasin B binding characteristics of the hepatic glucose carrier.
    Biochemistry. 1983 Apr 26;22(9):2222-7 PMID: 6683102
  60. Transport of potassium, amino acids, and glucose in cells transformed by Rous sarcoma virus.
    Fed Proc. 1984 Jan;43(1):107-12 PMID: 6317462
  61. Insulin action on glucose transport in cardiac muscle.
    J Biol Chem. 1984 Nov 10;259(21):13117-22 PMID: 6386808
  62. Sequence and structure of a human glucose transporter.
    Science. 1985 Sep 6;229(4717):941-5 PMID: 3839598
  63. Autoimmunity to insulin, beta cell dysfunction, and development of insulin-dependent diabetes mellitus.
    Diabetes. 1986 Feb;35(2):139-42 PMID: 3510920
  64. Glucose deprivation and hexose transporter polypeptides of murine fibroblasts.
    J Biol Chem. 1986 May 25;261(15):6778-89 PMID: 3700414
  65. The kinetics of glucose transport in human red blood cells.
    Biochim Biophys Acta. 1986 May 28;857(2):146-54 PMID: 3707948
  66. Structural basis of human erythrocyte glucose transporter function in reconstituted vesicles.
    J Biol Chem. 1986 Jun 5;261(16):7101-4 PMID: 3711076
  67. Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein.
    Proc Natl Acad Sci U S A. 1986 Aug;83(16):5784-8 PMID: 3016720
  68. Hormonal regulation of mammalian glucose transport.
    Annu Rev Biochem. 1986;55:1059-89 PMID: 3527041
  69. Modulation of basal glucose transporter Km in the adipocyte by insulin and other factors.
    J Biol Chem. 1986 Nov 15;261(32):15090-6 PMID: 3533934
  70. Glucose and insulin co-regulate the glucose transport system in primary cultured adipocytes. A new mechanism of insulin resistance.
    J Biol Chem. 1987 Jan 5;262(1):189-97 PMID: 3539929
  71. Loss of insulin response to glucose but not arginine during the development of autoimmune diabetes in BB/W rats: relationships to islet volume and glucose transport rate.
    Proc Natl Acad Sci U S A. 1986 Dec;83(24):9749-53 PMID: 3540950
  72. Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man.
    J Clin Invest. 1987 Feb;79(2):657-61 PMID: 3027132
  73. Photolabelling of the hexose transporter at external and internal sites: fragmentation patterns and evidence for a conformational change.
    Biochim Biophys Acta. 1987 Mar 12;897(3):395-405 PMID: 3545294
  74. Fourier transform infrared spectroscopic study of the structure and conformational changes of the human erythrocyte glucose transporter.
    J Biol Chem. 1987 Mar 15;262(8):3502-9 PMID: 3818652
  75. Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription.
    Science. 1987 Mar 20;235(4795):1495-8 PMID: 3029870
  76. Peptide-specific antibodies as probes of the orientation of the glucose transporter in the human erythrocyte membrane.
    J Biol Chem. 1987 Jul 5;262(19):9347-52 PMID: 3597413
  77. Trafficking of glucose transporters in 3T3-L1 cells. Inhibition of trafficking by phenylarsine oxide implicates a slow dissociation of transporters from trafficking proteins.
    Biochem J. 1992 Feb 1;281 ( Pt 3):809-17 PMID: 1536656
  78. Human intestinal glucose transporter expression and localization of GLUT5.
    Am J Physiol. 1992 Mar;262(3 Pt 1):C795-800 PMID: 1550217
  79. Amino acid substitutions at tryptophan 388 and tryptophan 412 of the HepG2 (Glut1) glucose transporter inhibit transport activity and targeting to the plasma membrane in Xenopus oocytes.
    J Biol Chem. 1992 Apr 15;267(11):7770-6 PMID: 1560011
  80. The efficient intracellular sequestration of the insulin-regulatable glucose transporter (GLUT-4) is conferred by the NH2 terminus.
    J Cell Biol. 1992 May;117(4):729-43 PMID: 1577853
  81. Complex regulation of simple sugar transport in insulin-responsive cells.
    Trends Biochem Sci. 1992 May;17(5):197-201 PMID: 1595129
  82. Kinetic resolution of the separate GLUT1 and GLUT4 glucose transport activities in 3T3-L1 cells.
    Biochem J. 1992 May 15;284 ( Pt 1):275-82 PMID: 1599406
  83. Kinetics of glucose transport in rat muscle: effects of insulin and contractions.
    Am J Physiol. 1987 Jul;253(1 Pt 1):E12-20 PMID: 3300362
  84. Long-term effect of insulin on glucose transport and insulin binding in cultured adipocytes from normal and obese humans with and without non-insulin-dependent diabetes.
    J Clin Invest. 1987 Oct;80(4):1073-81 PMID: 3308958
  85. HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.
    Nature. 1987 Oct 15-21;329(6140):599-604 PMID: 3309680
  86. Size and shape of the Escherichia coli lactose permease measured in filamentous arrays.
    Biochemistry. 1987 Jul 28;26(15):4816-23 PMID: 3311155
  87. Insulin-induced translocation of glucose transporters in rat hindlimb muscles.
    FEBS Lett. 1987 Nov 16;224(1):224-30 PMID: 2960560
  88. Expression cloning and cDNA sequencing of the Na+/glucose co-transporter.
    Nature. 1987 Nov 26-Dec 2;330(6146):379-81 PMID: 2446136
  89. Glucose transporter oligomeric structure determines transporter function. Reversible redox-dependent interconversions of tetrameric and dimeric GLUT1.
    J Biol Chem. 1992 Nov 25;267(33):23829-38 PMID: 1429721
  90. Cell surface accessibility of GLUT4 glucose transporters in insulin-stimulated rat adipose cells. Modulation by isoprenaline and adenosine.
    Biochem J. 1992 Nov 15;288 ( Pt 1):325-30 PMID: 1445278
  91. Effect of diabetes on glucoregulation. From glucose transporters to glucose metabolism in vivo.
    Diabetes Care. 1992 Nov;15(11):1747-66 PMID: 1468312
  92. Comparison of GLUT4 and GLUT1 subcellular trafficking in basal and insulin-stimulated 3T3-L1 cells.
    J Biol Chem. 1993 Mar 5;268(7):4600-3 PMID: 8444835
  93. Pancreatic beta-cells express a low affinity glucose transporter: functional consequences in normal and diabetic states.
    Biochem Soc Trans. 1993 Feb;21(1):164-8 PMID: 8449285
  94. Metabolic control of sugar transport by derepression of cell surface glucose transporters. An insulin-independent recruitment-independent mechanism of regulation.
    J Biol Chem. 1993 Mar 25;268(9):6437-44 PMID: 8454616
  95. Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors.
    Biochem J. 1993 Mar 15;290 ( Pt 3):701-6 PMID: 8457197
  96. Differential targeting of glucose transporter isoforms heterologously expressed in Xenopus oocytes.
    Biochem J. 1993 Mar 15;290 ( Pt 3):707-15 PMID: 8457198
  97. Insulin and platelet-derived growth factor acutely stimulate glucose transport in 3T3-L1 fibroblasts independently of protein kinase C.
    Biochim Biophys Acta. 1993 Jun 6;1177(2):191-8 PMID: 8499489
  98. Metformin blocks downregulation of cell surface GLUT4 caused by chronic insulin treatment of rat adipocytes.
    Diabetes. 1993 Aug;42(8):1159-65 PMID: 8325447
  99. Use of bismannose photolabel to elucidate insulin-regulated GLUT4 subcellular trafficking kinetics in rat adipose cells. Evidence that exocytosis is a critical site of hormone action.
    J Biol Chem. 1993 Aug 25;268(24):17820-9 PMID: 8349666
  100. Transport of D-fructose and its analogues by Trypanosoma brucei.
    Mol Biochem Parasitol. 1993 Jul;60(1):9-18 PMID: 8366898
  101. The blood-nerve barrier is rich in glucose transporter.
    J Neurocytol. 1988 Apr;17(2):173-8 PMID: 3060567
  102. Identification of the glucose transporter in mammalian cell membranes with a 125I-forskolin photoaffinity label.
    Biochem J. 1988 Nov 1;255(3):983-90 PMID: 3063259
  103. In vitro effects of sulfonylurea on glucose transport and translocation of glucose transporters in adipocytes from streptozocin-induced diabetic rats.
    Diabetes. 1989 Feb;38(2):205-11 PMID: 2492475
  104. Molecular cloning and characterization of an insulin-regulatable glucose transporter.
    Nature. 1989 Mar 2;338(6210):83-7 PMID: 2645527
  105. Identification of a novel gene encoding an insulin-responsive glucose transporter protein.
    Cell. 1989 Apr 21;57(2):305-15 PMID: 2649253
  106. A glucose transport protein expressed predominately in insulin-responsive tissues.
    Proc Natl Acad Sci U S A. 1989 Apr;86(8):2535-9 PMID: 2649883
  107. Localization of the pancreatic beta cell glucose transporter to specific plasma membrane domains.
    Science. 1989 Jul 21;245(4915):295-7 PMID: 2665080
  108. Sequence and structure of the yeast galactose transporter.
    J Bacteriol. 1989 Aug;171(8):4486-93 PMID: 2666404
  109. Differential regulation of two glucose transporters in adipose cells from diabetic and insulin-treated diabetic rats.
    J Clin Invest. 1989 Aug;84(2):404-11 PMID: 2668332
  110. The dynamics of the glucose transporter.
    Trends Biochem Sci. 1988 Jun;13(6):226-31 PMID: 3076284
  111. Functional expression of the human HepG2 and rat adipocyte glucose transporters in Xenopus oocytes. Comparison of kinetic parameters.
    J Biol Chem. 1989 Nov 15;264(32):18884-9 PMID: 2553725
  112. Developmentally regulated gene from Leishmania encodes a putative membrane transport protein.
    Proc Natl Acad Sci U S A. 1989 Oct;86(20):7682-6 PMID: 2813352
  113. Transformation stimulates glucose transporter gene expression in the absence of protein kinase C.
    Proc Natl Acad Sci U S A. 1989 Nov;86(21):8252-6 PMID: 2682641
  114. The hexose carrier from Chlorella. cDNA cloning of a eucaryotic H+-cotransporter.
    FEBS Lett. 1989 Dec 18;259(1):43-6 PMID: 2599110
  115. Identification of an intracellular pool of glucose transporters from basal and insulin-stimulated rat skeletal muscle.
    J Biol Chem. 1990 Jan 15;265(2):987-91 PMID: 2104834
  116. Inhibition of glucose transport into rat islet cells by immunoglobulins from patients with new-onset insulin-dependent diabetes mellitus.
    N Engl J Med. 1990 Mar 8;322(10):653-9 PMID: 2406597
  117. Molecular biology of mammalian glucose transporters.
    Diabetes Care. 1990 Mar;13(3):198-208 PMID: 2407475
  118. Glucose transporter levels in spontaneously obese (db/db) insulin-resistant mice.
    J Clin Invest. 1990 Mar;85(3):962-7 PMID: 2312736
  119. The high Km glucose transporter of islets of Langerhans is functionally similar to the low affinity transporter of liver and has an identical primary sequence.
    J Biol Chem. 1990 Apr 25;265(12):6548-51 PMID: 2182619
  120. C-terminal truncated glucose transporter is locked into an inward-facing form without transport activity.
    Nature. 1990 Jun 7;345(6275):550-3 PMID: 2348864
  121. Regulation of beta-cell glucose transporter gene expression.
    Proc Natl Acad Sci U S A. 1990 Jun;87(11):4088-92 PMID: 2190214
  122. Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM.
    Diabetes. 1990 Jul;39(7):865-70 PMID: 2354749
  123. Regulation of glucose-transporter gene expression in vitro and in vivo.
    Diabetes Care. 1990 Jun;13(6):548-64 PMID: 2192844
  124. Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6).
    J Biol Chem. 1990 Aug 5;265(22):13276-82 PMID: 1695905
  125. Primary structure, genomic organization and heterologous expression of a glucose transporter from Arabidopsis thaliana.
    EMBO J. 1990 Oct;9(10):3045-50 PMID: 2209537
  126. Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester.
    J Biol Chem. 1990 Oct 25;265(30):18172-9 PMID: 2211693
  127. Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes.
    Science. 1990 Oct 26;250(4980):546-9 PMID: 2237405
  128. Reduced beta-cell glucose transporter in new onset diabetic BB rats.
    J Clin Invest. 1990 Nov;86(5):1615-22 PMID: 2243134
  129. Sequence and genetic organization of a Zymomonas mobilis gene cluster that encodes several enzymes of glucose metabolism.
    J Bacteriol. 1990 Dec;172(12):7227-40 PMID: 2254282
  130. Liver glucose transporter: a basolateral protein in hepatocytes and intestine and kidney cells.
    Am J Physiol. 1990 Dec;259(6 Pt 1):C279-85 PMID: 1701966
  131. Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity.
    J Clin Invest. 1991 Mar;87(3):1072-81 PMID: 1999488
  132. Decreased expression of glucose transporter in muscle from insulin-resistant patients.
    Am J Physiol. 1991 Mar;260(3 Pt 1):E459-63 PMID: 2003599
  133. Diabetic hyperglycemia: link to impaired glucose transport in pancreatic beta cells.
    Science. 1991 Mar 8;251(4998):1200-5 PMID: 2006409
  134. Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat.
    J Cell Biol. 1991 Apr;113(1):123-35 PMID: 2007617
  135. Adipose tissue glucose transporters in NIDDM. Decreased levels of muscle/fat isoform.
    Diabetes. 1991 Apr;40(4):472-7 PMID: 2010047
  136. Substitution of leucine for tryptophan 412 does not abolish cytochalasin B labeling but markedly decreases the intrinsic activity of GLUT1 glucose transporter.
    J Biol Chem. 1991 Apr 25;266(12):7769-73 PMID: 2019601
  137. Chronic treatment with insulin selectively down-regulates cell-surface GLUT4 glucose transporters in 3T3-L1 adipocytes.
    J Biol Chem. 1991 Jun 25;266(18):11726-31 PMID: 2050674
  138. Association of Metformin's effect to increase insulin-stimulated glucose transport with potentiation of insulin-induced translocation of glucose transporters from intracellular pool to plasma membrane in rat adipocytes.
    Diabetes. 1991 Jul;40(7):850-7 PMID: 1647995
  139. Intracellular targeting of the insulin-regulatable glucose transporter (GLUT4) is isoform specific and independent of cell type.
    J Cell Biol. 1991 Aug;114(4):689-99 PMID: 1651337
  140. Translocation of the glucose transporter GLUT4 in cardiac myocytes of the rat.
    Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7815-9 PMID: 1881917
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj2950329
Published
1993-10-15
Pages
329-41
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1134886
Subset
IM
External Links
PubMed source DOI: 10.1042/bj2950329 PMC Full Text View journal details
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