Intermittent high-dose vitamin C therapy in patients with HTLV-I associated myelopathy.

Journal of neurology, neurosurgery, and psychiatry ·Vol. 56 ·No. 11 ·1993-11-00 ·Pages 1213-6

Kataoka A, Imai H, Inayoshi S, Tsuda T

Abstract

The efficacy of intermittent high-dose vitamin C therapy was evaluated in seven patients with HTLV-I-associated myelopathy (HAM). All HAM patients responded well to this therapy without serious side effects. Grade of disability score improved at 9.7 (SD 5.8) months after the therapy from 7.1 (3.3) to 3.6 (2.0) (p < 0.01). Serum immunosuppressive acidic protein was elevated before and decreased after the therapy from 747 (316) to 398 (86) micrograms/ml (p < 0.05), suggesting favourable immunomodulatory action of vitamin C therapy in HAM patients.

MeSH Terms

Adult Aged Aged, 80 and over Ascorbic Acid/administration & dosage Brain/physiopathology Evoked Potentials, Somatosensory Female HTLV-I Antibodies/analysis Humans Male Middle Aged Neoplasm Proteins/blood Paraparesis, Tropical Spastic/blood,drug therapy,physiopathology

Chemicals

HTLV-I Antibodies Neoplasm Proteins immunosuppressive acidic protein Ascorbic Acid

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Kataoka A

Third Department of Internal Medicine, Oita Medical University, Japan.

Imai H

Inayoshi S

Tsuda T

References (13)

13 references, click to expand

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Article Info

Journal

Journal of neurology, neurosurgery, and psychiatry

Abbr.

J Neurol Neurosurg Psychiatry

ISSN

0022-3050

DOI

10.1136/jnnp.56.11.1213

Published

1993-11-00

Pages

1213-6

Language

English

Region

England

NLM ID

2985191R

PMCID

PMC489823

Subset

External Links

PubMed source DOI: 10.1136/jnnp.56.11.1213 PMC Full Text View journal details

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Intermittent high-dose vitamin C therapy in patients with HTLV-I associated myelopathy.

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