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PMID: 8225579 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Identification of coccoid Escherichia coli BJ4 cells in the large intestine of streptomycin-treated mice.

Infection and immunity ·Vol. 61 ·No. 12 ·1993-12-00 ·Pages 5029-34

Krogfelt KA, Poulsen LK, Molin S

Abstract

Escherichia coli BJ4, a rat isolate, was used to examine the growth and differentiation of the microorganism in its natural habitat, the intestine. Growth of E. coli BJ4 in the large intestine of streptomycin-treated mice was compared with its growth in laboratory media. By a number of methods, it was shown that E. coli BJ4 differentiates, during growth in the intestine, into two distinct populations, one that has the characteristics of the laboratory-grown strain and one that appears as a coccoid cell. Furthermore, it was shown that there is a natural selection for the coccoid-type cell in the intestine, while in laboratory media growth of rod-shaped E. coli BJ4 is enhanced.

MeSH Terms
Animals Cecum/microbiology Cell Differentiation Culture Media Escherichia coli/cytology,growth & development,isolation & purification Feces/microbiology Female Intestine, Large/drug effects,microbiology Mice Models, Biological Rats Streptomycin/pharmacology
Chemicals
Culture Media Streptomycin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Krogfelt K A
Department of Bacteriology, Statens Seruminstitut, Copenhagen.
Poulsen L K
Molin S
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.61.12.5029-5034.1993
Published
1993-12-00
Pages
5029-34
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC281279
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.61.12.5029-5034.1993 PMC Full Text View journal details
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