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PMID: 8207440 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The subunit composition of a GABAA/benzodiazepine receptor from rat cerebellum.

Journal of neurochemistry ·Vol. 63 ·No. 1 ·1994-07-00 ·Pages 371-4

Khan ZU, Gutierrez A, De Blas AL

Abstract

The pentameric subunit composition of a large population (36%) of the cerebellar granule cell GABAA receptors that show diazepam (or clonazepam)-insensitive [3H]Ro 15-4513 binding has been determined by immunoprecipitation with subunit-specific antibodies. These receptors have alpha 6, alpha 1, gamma 2S, gamma 2L, and beta 2 or beta 3 subunits colocalizing in the same receptor complex.

MeSH Terms

Amino Acid Sequence Animals Antibodies/analysis,immunology Cerebellum/chemistry,cytology,ultrastructure Diazepam/pharmacology Molecular Sequence Data Precipitin Tests Rats Receptors, GABA-A/analysis,chemistry,immunology

Chemicals

Antibodies Receptors, GABA-A Diazepam

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Khan Z U

Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City 64110-2499.

Gutierrez A

De Blas A L

Article Info

Journal

Journal of neurochemistry

Abbr.

J Neurochem

ISSN

0022-3042

DOI

10.1046/j.1471-4159.1994.63010371.x

Published

1994-07-00

Pages

371-4

Language

English

Region

England

NLM ID

2985190R

Subset

Grants

NINDS NIH HHS · NS17708 · United States

External Links

PubMed source DOI: 10.1046/j.1471-4159.1994.63010371.x View journal details

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The subunit composition of a GABAA/benzodiazepine receptor from rat cerebellum.

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