Enzymatic modification of aminoglycoside antibiotics: a new 6'-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.

Antimicrobial agents and chemotherapy ·Vol. 9 ·No. 6 ·1976-06-00 ·Pages 945-50

Haas M, Biddlecome S, Davies J, Luce CE, Daniels PJ

Abstract

We describe an aminoglycoside 6'-N-acetyltransferase, isolated from Pseudomonas aeruginosa, that exhibits a novel substrate profile characterized by markedly reduced activity towards butirosin and amikacin.

MeSH Terms

Acetyltransferases/isolation & purification,metabolism Aminoglycosides/biosynthesis Anti-Bacterial Agents/biosynthesis Conjugation, Genetic Drug Resistance, Microbial Pseudomonas aeruginosa/drug effects,enzymology Sisomicin/metabolism

Chemicals

Aminoglycosides Anti-Bacterial Agents Acetyltransferases Sisomicin

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Haas M

Biddlecome S

Davies J

Luce C E

Daniels P J

References (8)

8 references, click to expand

Transferrable resistance to tobramycin in Klebsiella pneumoniae and Enterobacter cloacae associated with enzymatic acetylation of tobramycin.
Antimicrob Agents Chemother. 1974 Oct;6(4):492-7 PMID: 4157351
[Resistance to aminosides induced by an isoenzyme, kanamycin acetyltransferase].
Biochimie. 1974;56(6-7):893-7 PMID: 4614862
Aminoglycoside-modifying enzymes.
Methods Enzymol. 1975;43:611-28 PMID: 166284
The structure of sisomicin, a novel unsaturated aminocyclitol antibiotic from Micromonospora inyoensis.
J Org Chem. 1974 May 31;39(11):1451-7 PMID: 4833504
Utilization of carbon and nitrogen sources by Streptomyces kanamyceticus for kanamycin production.
Antimicrob Agents Chemother. 1973 Jul;4(1):6-10 PMID: 4791483
Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor.
Biochemistry. 1971 May 11;10(10):1787-96 PMID: 4935296
Isolation and structure of kanamycin inactivated by a cell free system of kanamycin-resistant E. coli.
J Antibiot (Tokyo). 1967 Jul;20(3):136-41 PMID: 4863032
R factor-mediated aminoglycoside antibiotic resistance in Pseudomonas aeruginosa: a new aminoglycoside 6'-N-acetyltransferase.
Antimicrob Agents Chemother. 1975 May;7(5):494-9 PMID: 807154

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.9.6.945

Published

1976-06-00

Pages

945-50

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC429655

Subset

External Links

PubMed source DOI: 10.1128/AAC.9.6.945 PMC Full Text View journal details

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Enzymatic modification of aminoglycoside antibiotics: a new 6'-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.

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