Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death.

Current opinion in genetics & development ·Vol. 4 ·No. 1 ·1994-02-00 ·Pages 102-8

Amati B, Land H

Abstract

The Myc oncoprotein dimerizes with its partner, Max, to bind DNA, activate transcription, and promote cell proliferation, as well as programmed cell death. Max also forms homodimers or heterodimers with its alternative partners, Mad and Mxi-1. These complexes behave as antagonists of Myc/Max through competition for common DNA targets, and perhaps permit cellular differentiation.

MeSH Terms

Animals Apoptosis/physiology Base Sequence Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Basic-Leucine Zipper Transcription Factors Binding Sites Cell Cycle/physiology Cell Differentiation/physiology DNA/genetics,metabolism DNA-Binding Proteins/physiology Helix-Loop-Helix Motifs/physiology Humans Leucine Zippers/physiology Proto-Oncogene Proteins c-myc/physiology Repressor Proteins Transcription Factors/physiology

Chemicals

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Basic-Leucine Zipper Transcription Factors DNA-Binding Proteins MAX protein, human MXD1 protein, human Myc associated factor X Proto-Oncogene Proteins c-myc Repressor Proteins Transcription Factors DNA

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Amati B

Imperial Cancer Research Fund, London, UK.

Land H

Article Info

Journal

Current opinion in genetics & development

Abbr.

Curr Opin Genet Dev

ISSN

0959-437X

DOI

10.1016/0959-437x(94)90098-1

Published

1994-02-00

Pages

102-8

Language

English

Region

England

NLM ID

9111375

Subset

External Links

PubMed source DOI: 10.1016/0959-437x(94)90098-1 View journal details

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Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death.

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