Home LiteratureArticle Details
PMID: 8188317 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The IgG2a antibody response to thyroglobulin is linked to the Igh locus in mouse.

Immunogenetics ·Vol. 39 ·No. 6 ·1994-00-00 ·Pages 404-11

Kuppers RC, Epstein LD, Outschoorn IM, Rose NR

Abstract

The IgG-subclass usage by several strains of mice in the response to immunization with mouse thyroglobulin (mTg) was examined in the experimental autoimmune thyroiditis model. While the subclass usage by most mouse strains was similar, the Ighb allotype-bearing mice consistently produced lower IgG2a levels to mTg. Using CBA-Ighb congenic and recombinant inbred strains of mice, the lower level of IgG2a in the Ighb mouse was mapped to the Igh locus. The regulation of IgG2a appeared to be cis controlled, as the CBA x C57BL/6F1 mouse also produced reduced IgG2a of the Ighb (B6) allotype but not of the Ighj (CBA) allotype.

MeSH Terms
Animals Chromosome Mapping Crosses, Genetic Gene Expression Regulation Genetic Linkage Haplotypes/genetics Immunoglobulin G/genetics Immunoglobulin Heavy Chains/genetics Mice Mice, Inbred CBA Thyroglobulin/immunology Thyroiditis, Autoimmune/genetics,immunology
Chemicals
Immunoglobulin G Immunoglobulin Heavy Chains Thyroglobulin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kuppers R C
Department of Immunology and Infectious Disease, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205.
Epstein L D
Outschoorn I M
Rose N R
References (28)
28 references, click to expand
  1. A gene linked to the Igh-C locus controls the production of rheumatoid factor in the mouse.
    J Exp Med. 1981 Mar 1;153(3):738-42 PMID: 6972988
  2. Gm and Km allotypes, immune response and disease susceptibility.
    Monogr Allergy. 1986;19:52-70 PMID: 3093851
  3. The influence of Igh-1 genes on the class and subclass distribution of oxazolone-specific antibodies.
    Immunogenetics. 1985;21(5):429-43 PMID: 3922883
  4. IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.
    J Immunol. 1988 Feb 15;140(4):1022-7 PMID: 3125247
  5. H-2 gene products influence susceptibility of target thyroid gland to damage in experimental autoimmune thyroiditis.
    Eur J Immunol. 1980 Feb;10(2):156-9 PMID: 6966223
  6. Natural infection of man with group A streptococci. Levels; restriction in class, subclass, and type; and clonal appearance of polysaccharide-group-specific antibodies.
    Scand J Immunol. 1976;5(4):383-90 PMID: 821139
  7. Autoimmune murine thyroiditis. IV. Localization of genetic control of the immune response.
    J Immunol. 1974 Mar;112(3):965-9 PMID: 4204563
  8. Recognition of idiotypes in lymphocyte interactions. I. Idiotypic selectivity in the cooperation between T and B lymphocytes.
    Eur J Immunol. 1978 Dec;8(12):846-52 PMID: 83234
  9. Molecular, cellular and systemic mechanisms for regulating IgCH expression.
    Immunol Rev. 1982;67:5-31 PMID: 6751995
  10. Genetic control of the IgG2a response to sheep erythrocytes in mice: isotype- and antigen-specific T cell-mediated suppression in low responders.
    J Immunol. 1979 Jun;122(6):2534-40 PMID: 87467
  11. IgG2 subclass restriction of antibody to pneumococcal polysaccharides.
    Clin Exp Immunol. 1986 Jan;63(1):127-34 PMID: 3955880
  12. Towards a comprehensive view of immunoglobulin class switching.
    Immunol Today. 1993 Jan;14(1):15-7 PMID: 8442856
  13. The induction of organ-specific antibodies during the graft-vs.-host reaction.
    Eur J Immunol. 1988 Jan;18(1):161-6 PMID: 3345793
  14. Influence of Igh-linked gene products on the generation of T helper cells in the response to sheep erythrocytes.
    J Exp Med. 1981 May 1;153(5):1225-35 PMID: 6788888
  15. Regulatory idiotypes. T helper cells recognize a shared VH idiotope on phosphorylcholine-specific antibodies.
    J Exp Med. 1982 Aug 1;156(2):539-49 PMID: 6808074
  16. T cell-induced suppression of IgG2ab expression in vivo leads to a large reduction of C gamma 2ab mRNA levels.
    J Immunol. 1993 Feb 1;150(3):858-66 PMID: 8423342
  17. Studies on human antibodies. VI. Selective variations in subgroup composition and genetic markers.
    J Exp Med. 1968 Mar 1;127(3):633-46 PMID: 4169968
  18. Rheumatoid factors in 129XB recombinant inbred strains. Igh-1-linked control of allotypic and isotypic specificities.
    J Exp Med. 1984 Feb 1;159(2):355-64 PMID: 6420498
  19. Idiotypic analysis of anti-GAT antibodies. VIII. Comparison of interstrain and allotype-associated idiotypic specificities.
    J Immunol. 1981 Jan;126(1):177-82 PMID: 6161159
  20. Autoimmune murine thyroiditis relation to histocompatibility (H-2) type.
    Science. 1971 Dec 10;174(4014):1137-9 PMID: 5133731
  21. Autoantibodies to thyroglobulin are encoded by diverse V-gene segments and recognize restricted epitopes.
    J Immunol. 1990 Sep 15;145(6):1768-75 PMID: 1697309
  22. T cell regulation of the IgG2a response to TNP-Ficoll: evidence that allotype congenic mice contain both helper cells that preferentially enhance IgG2a synthesis and suppressor cells that specifically suppress IgG2 synthesis.
    J Immunol. 1982 Jun;128(6):2405-10 PMID: 6210729
  23. Influence of the Ig H chain locus on autoantibody production in autoimmune mice.
    J Immunol. 1992 Dec 1;149(11):3735-40 PMID: 1431145
  24. IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide.
    J Immunol. 1988 Apr 1;140(7):2121-7 PMID: 3127461
  25. Linkage of murine (T,G)-A--L-specific idiotypic determinants to the heavy chain constant region allotypic markers.
    Immunogenetics. 1980;11(2):191-8 PMID: 6773883
  26. Regulation of experimental autoimmune thyroiditis: mapping of susceptibility to the I-A subregion of the mouse H-2.
    Immunogenetics. 1982;15(4):427-30 PMID: 6804377
  27. Relationship of idiotypes of the anti-p-azophenylarsonate antibodies of A/J and BALB/c mice.
    J Immunol. 1981 Apr;126(4):1268-73 PMID: 6162884
  28. Regulation of experimental autoimmune thyroiditis: influence of non-H-2 genes.
    J Immunogenet. 1982 Aug;9(4):257-65 PMID: 6811667
Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF00176157
Published
1994-00-00
Pages
404-11
Language
English
Region
United States
NLM ID
0420404
Subset
IM
Grants
NIAMS NIH HHS · R01AR31632 · United States
NIAID NIH HHS · U01AI35043 · United States
External Links
PubMed source DOI: 10.1007/BF00176157 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2