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PMID: 8171027 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Functional synergism between putative gamma-aminobutyrate-containing neurons and pyramidal neurons in prefrontal cortex.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 9 ·1994-04-26 ·Pages 4009-13

Wilson FA, O'Scalaidhe SP, Goldman-Rakic PS

Abstract

The responses of putative gamma-aminobutyratergic interneurons (fast-spiking) and pyramidal (regular-spiking) cell pairs were compared in monkeys performing visual and memory-guided oculomotor tasks. Both fast- and regular-spiking neurons had similar receptive fields, indicating that gamma-aminobutyratergic interneurons carry a specific informational signal, as opposed to providing nonspecific modulation. However, the responses of the pairs were inverted and the timing of excitatory and inhibitory responses appeared to be phased, a property consistent with gamma-aminobutyrate-mediated shaping of receptive fields. These observations (i) provide evidence that interneurons and pyramidal cells can be differentiated in vivo and (ii) begin to elucidate the role of gamma-aminobutyratergic mechanisms in cognition.

MeSH Terms
Action Potentials Animals Cerebral Cortex/physiology Interneurons/physiology Macaca mulatta Memory/physiology Visual Pathways/physiology gamma-Aminobutyric Acid/physiology
Chemicals
gamma-Aminobutyric Acid
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Wilson F A
Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510.
O'Scalaidhe S P
Goldman-Rakic P S
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.91.9.4009
Published
1994-04-26
Pages
4009-13
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC43712
Subset
IM
Grants
NIMH NIH HHS · MH38546 · United States
NIMH NIH HHS · MH44866 · United States
External Links
PubMed source DOI: 10.1073/pnas.91.9.4009 PMC Full Text View journal details
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