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PMID: 8163168 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Sequences of the oxytetracycline polyketide synthase-encoding otc genes from Streptomyces rimosus.

Gene ·Vol. 141 ·No. 1 ·1994-04-08 ·Pages 141-2

Kim ES, Bibb MJ, Butler MJ, Hopwood DA, Sherman DH

Abstract

The complete nucleotide sequences of the Streptomyces rimosus oxytetracycline (oxyTc) polyketide synthase (PKS)-encoding genes (otcY) has been determined, revealing three open reading frames. The deduced amino-acid sequences correspond to the presumed heterodimeric beta-ketoacyl synthase and acyl carrier protein found in other type-II (multicomponent) PKS systems that specify construction of acetate-derived polyketide antibiotics.

Related Genes

otcY

MeSH Terms

Amino Acid Sequence Genes, Bacterial/genetics Molecular Sequence Data Multienzyme Complexes/chemistry,genetics Oxytetracycline/biosynthesis Restriction Mapping Sequence Analysis, DNA Sequence Homology, Amino Acid Streptomyces/enzymology,genetics

Chemicals

Multienzyme Complexes Oxytetracycline

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Kim E S

Department of Microbiology, University of Minnesota, St. Paul 55108.

Bibb M J

Butler M J

Hopwood D A

Sherman D H

Article Info

Journal

Gene

Abbr.

Gene

ISSN

0378-1119

DOI

10.1016/0378-1119(94)90144-9

Published

1994-04-08

Pages

141-2

Language

English

Region

Netherlands

NLM ID

7706761

Subset

Grants

NIGMS NIH HHS · GM-39784 · United States

NIGMS NIH HHS · GM-46884 · United States

Databases

GENBANK

Z25538

External Links

PubMed source DOI: 10.1016/0378-1119(94)90144-9 View journal details

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Sequences of the oxytetracycline polyketide synthase-encoding otc genes from Streptomyces rimosus.

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