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PMID: 8159706 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Synaptic disinhibition during maintenance of long-term potentiation in the CA1 hippocampal subfield.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 8 ·1994-04-12 ·Pages 3058-62

Stelzer A, Simon G, Kovacs G, Rai R

Abstract

Long-term potentiation (LTP) in the CA1 region of the hippocampus is widely believed to occur through a strengthening of efficacy of excitatory synapses between afferent fibers and pyramidal cells. An alternative mechanism of LTP, reduction of efficacy of synaptic inhibition, was examined in the present report. The present study demonstrates that the maintenance of LTP in the CA1 hippocampal subfield of guinea pigs is accompanied by impairment of type A gamma-aminobutyric acid (GABA) receptor function, particularly at apical dendritic sites of CA1 pyramidal cells. Enhanced excitability of GABAergic interneurons during LTP represents a strengthening of inhibitory efficacy. The net effect of opposite modifications of synaptic inhibition during LTP of CA1 pyramidal cells is an overall impairment of the strength of GABAergic inhibition, and disinhibition could contribute importantly to CA1 pyramidal cell LTP.

MeSH Terms
Animals Guinea Pigs Hippocampus/physiology In Vitro Techniques Ion Channel Gating Long-Term Potentiation Neural Inhibition Pyramidal Tracts/physiology Receptors, GABA/physiology Receptors, N-Methyl-D-Aspartate/physiology Synapses/physiology gamma-Aminobutyric Acid/pharmacology
Chemicals
Receptors, GABA Receptors, N-Methyl-D-Aspartate gamma-Aminobutyric Acid
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Stelzer A
Department of Pharmacology, State University of New York, Brooklyn 11203.
Simon G
Kovacs G
Rai R
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35 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.91.8.3058
Published
1994-04-12
Pages
3058-62
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC43514
Subset
IM
Grants
NINDS NIH HHS · NS30144-01 · United States
External Links
PubMed source DOI: 10.1073/pnas.91.8.3058 PMC Full Text View journal details
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