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题目:: Characterization of rat pituitary cells by their responses to hypothalamic releasing hormones.
作者:: Kasahara(K),Tasaka(K),Masumoto(N),Mizuki(J),Tahara(M),Miyake(A),Tanizawa(O)
状态:: 发布时间1994-05-02 , 更新时间 2013-11-21
期刊:: Biochem Biophys Res Commun
摘要:: Rat pituitary cells in monolayer culture were characterized by their [Ca2+]i responses to hypothalamic releasing hormones, growth hormone (GHRH), thyrotropin-releasing hormone (TRH), gonadotropin-releasing hormone (GnRH) and corticotropin-releasing hormone (CRH). The percentages of the cell population responding to GHRH, TRH, GnRH, CRH and non-responding cells were 27.3%, 47.6%, 13.8%, 6.2% and 35.3%, respectively. Some of the cells responded to two or more of those hormones. In the GHRH-responding cells, the population of TRH-responding cells was 51.4%, In the TRH-responding cells, the population of GHRH-responding cells was 30.8%. Some of the GHRH-responding cells also responded to CRH and GnRH. In the GnRH-responding cells, the population of TRH-responding cells was 61.8%. In summary, GHRH-responding cells have an especially close relationship with TRH-responding cells, and GnRH-responding cells also have close relationship with TRH-responding cells. There is also some relationship between the populations responding to other pairs of releasing hormones. These findings suggest functional overlapping among each population of pituitary cells.
语言:: eng
DOI:: 10.1006/bbrc.1994.1391

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