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PMID: 8146130 Published · ppublish English Journal Article Review

Hepatitis viruses: changing patterns of human disease.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 7 ·1994-03-29 ·Pages 2401-6

Purcell RH

Abstract

Viral hepatitis is a disease of antiquity, but evidence for more than one etiologic agent has been recognized only since the 1940s, when two viruses (hepatitis A virus and hepatitis B virus) were thought to account for all disease. In the past 20 years, three additional hepatitis agents (hepatitis C virus, hepatitis D virus, and hepatitis E virus) have been discovered, and there is evidence for at least one additional virus. Each of the five recognized hepatitis viruses belongs to a different virus family, and each has a unique epidemiology. The medical impact of these viruses on society has been strongly influenced by changes in human ecology. This has resulted in some cases in diminished disease and in others in increases in the incidence of disease.

MeSH Terms
Behavior Hepacivirus/pathogenicity Hepatitis B virus/pathogenicity Hepatitis Delta Virus/pathogenicity Hepatitis E virus/pathogenicity Hepatitis, Viral, Human/epidemiology,microbiology,pathology Hepatovirus/pathogenicity Humans
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Purcell R H
Hepatitis Viruses Section, National Institute of Allergies and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.91.7.2401
Published
1994-03-29
Pages
2401-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC43379
Subset
IM
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1073/pnas.91.7.2401 PMC Full Text View journal details
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