Stimulation of human prolactin secretion by sulpiride.

Intramuscular injection of 100 mg of sulpiride significantly raised plasma human prolactin (hPRL) levels in all of 7 normal subjects examined. The mean (+SE) peak value was 78.0 +/- 16.6 ng/ml, which was observed 30 min after the injection. Daily administration of sulpiride (50 mg tid po) raised plasma hPRL levels in all 7 patients with peptic ulcer, with peak values obtained within 2 weeks. Lactation occurred in 2 of these patients. It is concluded that sulpiride stimulates hPRL secretion in man.