Home LiteratureArticle Details
PMID: 8129030 Published · ppublish English Journal Article Review

Paired helical filament tau in Alzheimer's disease. The kinase connection.

The American journal of pathology ·Vol. 144 ·No. 3 ·1994-03-00 ·Pages 449-53

Trojanowski JQ, Lee VM

Abstract

暂无摘要

MeSH Terms
Alzheimer Disease/metabolism,physiopathology Humans Phosphotransferases/physiology tau Proteins/chemistry,metabolism
Chemicals
tau Proteins Phosphotransferases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Trojanowski J Q
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-4283.
Lee V M
References (22)
22 references, click to expand
  1. A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.
    Science. 1991 Feb 8;251(4994):675-8 PMID: 1899488
  2. Tau protein and the neurofibrillary pathology of Alzheimer's disease.
    Trends Neurosci. 1993 Nov;16(11):460-5 PMID: 7507619
  3. Fetal-type phosphorylation of the tau in paired helical filaments.
    J Neurochem. 1992 May;58(5):1667-75 PMID: 1560225
  4. Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.
    EMBO J. 1992 Jun;11(6):2131-8 PMID: 1376245
  5. Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro.
    J Cell Biol. 1992 Aug;118(3):573-84 PMID: 1639844
  6. The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease.
    FEBS Lett. 1992 Sep 7;309(2):199-202 PMID: 1505683
  7. Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.
    J Biol Chem. 1992 Aug 25;267(24):17047-54 PMID: 1512244
  8. Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.
    Mol Biol Cell. 1992 Oct;3(10):1141-54 PMID: 1421571
  9. p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected].
    FEBS Lett. 1992 Nov 2;312(1):95-9 PMID: 1330687
  10. Proline-directed phosphorylation of human Tau protein.
    J Biol Chem. 1992 Nov 5;267(31):22570-4 PMID: 1429606
  11. Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.
    FEBS Lett. 1992 Dec 21;314(3):315-21 PMID: 1334849
  12. Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase.
    Neurosci Lett. 1992 Nov 23;147(1):58-62 PMID: 1336152
  13. Okadaic acid induces hyperphosphorylated forms of tau protein in human brain slices.
    Ann Neurol. 1993 Jan;33(1):77-87 PMID: 8494335
  14. Tau proteins are abnormally expressed in olfactory epithelium of Alzheimer patients and developmentally regulated in human fetal spinal cord.
    Exp Neurol. 1993 May;121(1):93-105 PMID: 8495714
  15. The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.
    Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5066-70 PMID: 8506352
  16. Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding.
    Neuron. 1993 Jun;10(6):1089-99 PMID: 8318230
  17. Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites.
    Brain Res. 1993 Aug 6;618(2):333-7 PMID: 8374766
  18. Expression of neuronal and glial polypeptides during histogenesis of the human cerebellar cortex including observations on the dentate nucleus.
    J Comp Neurol. 1993 Aug 15;334(3):356-69 PMID: 7690783
  19. Genetic and molecular advances in Alzheimer's disease.
    Trends Neurosci. 1993 Oct;16(10):398-403 PMID: 7504354
  20. Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease.
    Trends Neurosci. 1993 Oct;16(10):403-9 PMID: 7504355
  21. Altered tau and neurofilament proteins in neuro-degenerative diseases: diagnostic implications for Alzheimer's disease and Lewy body dementias.
    Brain Pathol. 1993 Jan;3(1):45-54 PMID: 8269083
  22. Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins).
    Lab Invest. 1992 Feb;66(2):212-22 PMID: 1735956
Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1994-03-00
Pages
449-53
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1887092
Subset
IM
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2