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PMID: 8121488 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene.

Nature ·Vol. 367 ·No. 6460 ·1994-01-20 ·Pages 236-42

Moreno S, Nurse P

Abstract

The rum1+ gene is identified as a new regulator of G1 progression in fission yeast. It influences three aspects of G1 regulation: determination of the length of G1, dependence of S phase upon completion of mitosis, and restraint of mitosis until G1 is finished. We propose that it has a central role in regulating the G1 phase of the cell cycle.

Related Genes

rum<up>+</up>

MeSH Terms

Amino Acid Sequence Base Sequence CDC2 Protein Kinase/metabolism Cell Cycle/genetics Cyclin B Cyclins/metabolism DNA Replication/genetics DNA, Fungal/biosynthesis Fungal Proteins/genetics,physiology G1 Phase/genetics Genes, Fungal Models, Genetic Molecular Sequence Data Mutation S Phase/genetics Schizosaccharomyces/cytology,genetics Schizosaccharomyces pombe Proteins Transformation, Genetic

Chemicals

Cyclin B Cyclins DNA, Fungal Fungal Proteins Rum1 protein, S pombe Schizosaccharomyces pombe Proteins CDC2 Protein Kinase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Moreno S

Department of Biochemistry, Oxford University, London, UK.

Nurse P

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/367236a0

Published

1994-01-20

Pages

236-42

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

X77730

Corrections

CommentIn

PMID: 8121487

External Links

PubMed source DOI: 10.1038/367236a0 View journal details

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Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene.

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