Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11.

FEBS letters ·Vol. 339 ·No. 3 ·1994-02-21 ·Pages 302-6

Uetz P, Abdelatty F, Villarroel A, Rappold G, Weiss B, Koenen M

Abstract

We have isolated the murine gene encoding the 5-HT3 receptor (5-HT3R), a member of the ligand-gated ion channels, that mediates a variety of physiological effects in central and peripheral neurons. DNA sequence analysis of the 5-HT3R gene revealed its organisation in 9 exons distributed over approximately 12 kbp of DNA. Alternative use of exon 9 splice acceptor sites generated two 5-HT3R variants. The 5-HT3R gene, whose structure is closely related to neuronal and muscle AChR alpha genes, as demonstrated by four common splice junctions, was localised on human chromosome 11.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Brain Chemistry Chromosome Mapping Chromosomes, Human, Pair 11 DNA, Complementary/isolation & purification Female Gene Expression Gene Transfer Techniques Humans Mice Molecular Sequence Data Muscles/chemistry Neurons/chemistry Oocytes/metabolism RNA Splicing Receptors, Serotonin/chemistry,genetics Sequence Analysis, DNA Sequence Homology Xenopus laevis

Chemicals

DNA, Complementary Receptors, Serotonin

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Uetz P

Abteilung Zellphysiologie, Max-Planck-Institut für Medizinische Forschung, Heidelberg, Germany.

Abdelatty F

Villarroel A

Rappold G

Weiss B

Koenen M

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(94)80435-4

Published

1994-02-21

Pages

302-6

Language

English

Region

England

NLM ID

0155157

Subset

Databases

GENBANK

Z22772, Z22773

External Links

PubMed source DOI: 10.1016/0014-5793(94)80435-4 View journal details

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Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11.

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