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PMID: 8107262 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Posttranscriptional effector domains in the Rev proteins of feline immunodeficiency virus and equine infectious anemia virus.

Journal of virology ·Vol. 68 ·No. 3 ·1994-03-00 ·Pages 1998-2001

Mancuso VA, Hope TJ, Zhu L, Derse D, Phillips T, Parslow TG

Abstract

By systematically dissecting the Rev proteins of feline immunodeficiency virus (FIV) and equine infectious anemia virus (EIAV), we have identified within each a short peptide that is functionally interchangeable with the effector domains found in Rev-like proteins from other retroviruses. The active sequences from FIV and EIAV differ in several respects from other known effectors and may represent a distinct class of effector domain.

MeSH Terms
Amino Acid Sequence DNA Mutational Analysis Gene Products, rev/genetics,pharmacology Immunodeficiency Virus, Feline/genetics Infectious Anemia Virus, Equine/genetics Molecular Sequence Data RNA Processing, Post-Transcriptional/drug effects Recombinant Proteins/pharmacology Sequence Homology, Amino Acid Structure-Activity Relationship
Chemicals
Gene Products, rev Recombinant Proteins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Mancuso V A
Department of Pathology, University of California, San Francisco 94143-0506.
Hope T J
Zhu L
Derse D
Phillips T
Parslow T G
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22 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.68.3.1998-2001.1994
Published
1994-03-00
Pages
1998-2001
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC236666
Subset
IM
Grants
NIAID NIH HHS · AI29313 · United States
NIGMS NIH HHS · GM43574 · United States
External Links
PubMed source DOI: 10.1128/JVI.68.3.1998-2001.1994 PMC Full Text View journal details
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