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PMID: 809654 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Effect of erythrocytes treated with enterobacterial common antigen on experimental Salmonella typhimurium infection of mice.

Medical microbiology and immunology ·Vol. 161 ·No. 3 ·1975-07-02 ·Pages 163-70

Gorzynski EA, Krasny SA

Abstract

The immunogenicity of enterobacterial common antigen (CA)-treated horse or mouse erythrocytes was determined in Swiss white albino mice by comparing survival rates with control mice, immunized with P. aeruginosa fraction-treated RBC and challenged in parallel with 10 LD50 S. typhimurium. The administration of small amounts of CA on horse, but not mouse, RBC significantly delayed mortality; protection was only marginally less than that evoked with 12-fold larger amounts of CA in the absence of RBC. Survival in infected animals was transient; independent of immunogen or control preparation employed, all mice were dead by day 15 after challenge.

MeSH Terms
Animals Antigens, Bacterial Erythrocytes Horses Immunization Male Mice Pseudomonas aeruginosa Salmonella Infections, Animal/immunology Salmonella typhimurium Time Factors
Chemicals
Antigens, Bacterial
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gorzynski E A
Krasny S A
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23 references, click to expand
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Article Info
Journal
Medical microbiology and immunology
Abbr.
Med Microbiol Immunol
ISSN
0300-8584
DOI
10.1007/BF02121006
Published
1975-07-02
Pages
163-70
Language
English
Region
Germany
NLM ID
0314524
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02121006 View journal details
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