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PMID: 808158 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Possible mechanism of decreased susceptibility of Neisseria gonorrhoeae to penicillin.

Antimicrobial agents and chemotherapy ·Vol. 7 ·No. 6 ·1975-06-00 ·Pages 788-92

Rodriguez W, Saz AK

Abstract

By use of (14)C-labeled benzyl penicillin, it has been established that beta-lactamases and/or acylases play no role in the resistance of Neisseria gonorrhoeae to penicillin. It has been found, however, that very susceptible strains of the organisms (minimal inhibitory concentration, 0.008 mug/ml) bind 10 to 15 times as much penicillin as do moderately to highly resistant strains of the gonoccoccus (minimal inhibitory concentration, 0.125 to 2.0 mug/ml). It is postulated that this degree of change in binding components of the whole cell and whole cytoplasmic membrane is sufficient to account for the decreased susceptibility of the organism to penicillin.

MeSH Terms
Neisseria gonorrhoeae/drug effects Penicillin Resistance Penicillinase/metabolism Penicillins/pharmacology
Chemicals
Penicillins Penicillinase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rodriguez W
Saz A K
References (26)
26 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.7.6.788
Published
1975-06-00
Pages
788-92
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC429227
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.7.6.788 PMC Full Text View journal details
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