Mitogenic effect of bacterial peptidoglycans possessing adjuvant activity.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 115 ·No. 1 ·1975-07-00 ·Pages 268-71

Damais C, Bona C, Chedid L, Fleck J, Nauciel C, Martin JP

Abstract

Two purified peptides extracted from E. coli or B. megaterium strongly stimulated the spleen lymphocytes of rabbits and of normal or nude mice. Both preparations can substitute for Mycobacteria in Freund's complete adjuvant. The peptidoglycan extracted from M. lysodeikticus by a similar procedure which lacks adjuvant activity, did not induce blast transformation. However, the monomere of the E. coli peptidoglycan was devoid of mitogenicity although it has also a marked adjuvant activity.

MeSH Terms

Adjuvants, Immunologic/toxicity Adrenalectomy Animals B-Lymphocytes/drug effects Bacillus megaterium/immunology Dose-Response Relationship, Drug Escherichia coli/immunology Lethal Dose 50 Lipopolysaccharides/toxicity Lymphocyte Activation/drug effects Mice Mice, Inbred AKR Mice, Nude Micrococcus/immunology Mitogens/toxicity Nocardia/immunology Peptidoglycan/toxicity Rabbits Spleen/immunology

Chemicals

Adjuvants, Immunologic Lipopolysaccharides Mitogens Peptidoglycan

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Damais C

Bona C

Chedid L

Fleck J

Nauciel C

Martin J P

Article Info

Journal

Journal of immunology (Baltimore, Md. : 1950)

Abbr.

J Immunol

ISSN

0022-1767

Published

1975-07-00

Pages

268-71

Language

English

Region

United States

NLM ID

2985117R

Subset

External Links

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Mitogenic effect of bacterial peptidoglycans possessing adjuvant activity.

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