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PMID: 807557 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Rifampin resistance mutation of Bacillus subtilis altering the electrophoretic mobility of the beta subunit of ribonucleic acid polymerase.

Journal of bacteriology ·Vol. 122 ·No. 3 ·1975-06-00 ·Pages 1387-90

Linn T, Losick R, Sonenshein AL

Abstract

The rifampin-resistance mutation of LS3,an asporogenous mutant of Bacillus subtilis 3610, leads to altered mobility of the beta subunit of ribonucleic acid polymerase in sodium dodecyl sulfate-polyacrylamide slab gel electrophoresis. This finding argues that the rifampin-resistance mutation is located in the structural gene coding for the beta polypeptide.

MeSH Terms
Bacillus subtilis/drug effects,enzymology,growth & development DNA-Directed RNA Polymerases/analysis Drug Resistance, Microbial Electrophoresis, Polyacrylamide Gel Genes Mutation Peptides/analysis Phenotype Rifampin/pharmacology Spores, Bacterial/growth & development Transformation, Genetic
Chemicals
Peptides DNA-Directed RNA Polymerases Rifampin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Linn T
Losick R
Sonenshein A L
References (12)
12 references, click to expand
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    Nature. 1970 Aug 29;227(5261):906-9 PMID: 4988656
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    Proc Natl Acad Sci U S A. 1970 Jun;66(2):404-10 PMID: 4988921
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    Nature. 1969 Oct 4;224(5214):35-7 PMID: 4980824
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.122.3.1387-1390.1975
Published
1975-06-00
Pages
1387-90
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC246195
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.122.3.1387-1390.1975 PMC Full Text View journal details
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