Pseudomonas aeruginosa lipopolysaccharide: an uncoupler of mitochondrial oxidative phosphorylation.

Canadian journal of microbiology ·Vol. 21 ·No. 6 ·1975-06-00 ·Pages 877-83

Greer GG, Milazzo FH

Abstract

The addition of Pseudomonas aeruginosa KCIIR LPS to respiring mitochondria stimulated the rate of substrate oxidation, reduced the respiratory control ratio, stimulated oxygen uptake in state 4, and released the inhibition imposed upon state 3 by atractyloside. It was concluded that LPS acted as an uncoupler of oxidative phosphorylation and that it produced effects similar to those observed with the classical uncoupler 2,4-dinitrophenol.

MeSH Terms

Adenosine Diphosphate/metabolism Animals Antimycin A Ascorbic Acid Atractyloside/antagonists & inhibitors Dinitrophenols/pharmacology Glutamates/metabolism Lipopolysaccharides/pharmacology Malates/metabolism Mitochondria, Liver/drug effects,metabolism Oxidative Phosphorylation/drug effects Oxygen Consumption/drug effects Pseudomonas aeruginosa Rats Rotenone Succinates/metabolism Tetramethylphenylenediamine Uncoupling Agents

Chemicals

Dinitrophenols Glutamates Lipopolysaccharides Malates Succinates Uncoupling Agents Rotenone Atractyloside Adenosine Diphosphate Antimycin A Tetramethylphenylenediamine Ascorbic Acid

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Greer G G

Milazzo F H

Article Info

Journal

Canadian journal of microbiology

Abbr.

Can J Microbiol

ISSN

0008-4166

DOI

10.1139/m75-130

Published

1975-06-00

Pages

877-83

Language

English

Region

Canada

NLM ID

0372707

Subset

External Links

PubMed source DOI: 10.1139/m75-130 View journal details

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Pseudomonas aeruginosa lipopolysaccharide: an uncoupler of mitochondrial oxidative phosphorylation.

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