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PMID: 8071898 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Differential modulation of chemical and electrical components of mixed synapses in the lobster stomatogastric ganglion.

Journal of comparative physiology. A, Sensory, neural, and behavioral physiology ·Vol. 175 ·No. 2 ·1994-08-00 ·Pages 233-49

Johnson BR, Peck JH, Harris-Warrick RM

Abstract

1. Two pairs of neurons in the pyloric network of the spiny lobster, Panulirus interruptus, communicate through mixed graded chemical and rectifying electrical synapses. The anterior burster (AB) chemically inhibits and is electrically coupled to the ventricular dilator (VD); the lateral pyloric (LP) and pyloric (PY) neurons show reciprocal chemical inhibition and electrical coupling. We examined the effects of dopamine (DA), serotonin (5HT) and octopamine (Oct) on these mixed synapses to determine the plasticity possible with opposing modes of synaptic interaction. 2. Dopamine increased net inhibition at all three pyloric mixed synapses by both reducing electrical coupling and increasing chemical inhibition. This reversed the sign of the net synaptic interaction when electrotonic coupling dominated some mixed synapses, and activated silent chemical components of other mixed synapses. 3. Serotonin weakly enhanced LP-->PY net inhibition, by reducing electrical coupling without altering chemical inhibition. Serotonin reduced AB-->VD electrical coupling, but variability in its effect on the chemical component made the net effect non-significant. 4. Octopamine enhanced LP-->PY and PY-->LP net inhibition by enhancing the chemical inhibitory component without altering electrical coupling. 5. Differential modulation of chemical and electrical components of mixed synapses markedly changes the net synaptic interactions. This contributes to the flexible outputs that modulators evoke from anatomically defined neural networks.

MeSH Terms
Animals Biogenic Amines/pharmacology Dopamine/pharmacology Electrophysiology Ganglia, Invertebrate/physiology Nephropidae/physiology Neural Inhibition/drug effects Neuronal Plasticity Octopamine/pharmacology Pylorus/innervation Serotonin/pharmacology Synapses/drug effects,physiology
Chemicals
Biogenic Amines Octopamine Serotonin Dopamine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Johnson B R
Section of Neurobiology and Behavior, S.G., Cornell University, Ithaca, NY 14853.
Peck J H
Harris-Warrick R M
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Article Info
Journal
Journal of comparative physiology. A, Sensory, neural, and behavioral physiology
Abbr.
J Comp Physiol A
DOI
10.1007/BF00215119
Published
1994-08-00
Pages
233-49
Language
English
Region
Germany
NLM ID
8413199
Subset
IM
Grants
NINDS NIH HHS · NS17323 · United States
External Links
PubMed source DOI: 10.1007/BF00215119
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