Home LiteratureArticle Details
PMID: 806649 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Killing in vitro of Trypanosoma cruzi by macrophages from mice immunized with T. cruzi or BCG, and absence of cross-immunity on challege in vivo.

The Journal of experimental medicine ·Vol. 142 ·No. 2 ·1975-08-01 ·Pages 299-311

Hoff R

Abstract

Peritoneal macrophages from T. cruzi-immune mice were resistant to infection in vitro with culture forms of the parasite. Macrophage resistance appeared in infected mice about 21 days postinfection when parasitemia was still rising. Resistance in vitro was nonspecific since macrophages from BCG-immune mice were resistant to T. cruzi, and since macrophages from T. cruzi-immune mice were resistant to infection in vitro with Listeria were not resistant to challenge with T. cruzi even when the parasites were opsonized.

MeSH Terms
Animals Ascitic Fluid/cytology BCG Vaccine Cell Count Cells, Cultured Cross Reactions Female Immunization Listeria monocytogenes/immunology Macrophages/immunology,parasitology Mice Mice, Inbred C3H Mycobacterium bovis/immunology Time Factors Trypanosoma cruzi/immunology
Chemicals
BCG Vaccine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hoff R
References (23)
23 references, click to expand
  1. Studies of in vitro infection by Trypanosoma cruzi. I. Ultrastructural studies on the invasion of macrophages and L-cells.
    Am J Trop Med Hyg. 1975 Jan;24(1):25-33 PMID: 1089367
  2. A method for counting and concentrating living Trypanosoma cruzi in blood lysed with ammonium chloride.
    J Parasitol. 1974 Jun;60(3):527-8 PMID: 4209381
  3. The enhancement of macrophage bacteriostasis by products of activated lymphocytes.
    J Exp Med. 1973 Oct 1;138(4):952-64 PMID: 4200649
  4. Trypanosoma cruzi: interaction with vertebrate cells in vitro. 3. Selection for biological characteristics following intracellular passage.
    Exp Parasitol. 1974 Aug;36(1):143-9 PMID: 4602987
  5. Correspondence: Transfer of immunity to T. cruzi.
    Trans R Soc Trop Med Hyg. 1974;68(4):338 PMID: 4608106
  6. Metabolic and functonal studies on activated mouse macrophages.
    J Exp Med. 1973 Feb 1;137(2):537-42 PMID: 4631141
  7. Lymphocyte transformation in Chagas disease.
    Infect Immun. 1972 Dec;6(6):905-8 PMID: 4629392
  8. Developmental cycles of Trypanosoma (Schizotrypanum) cruzi (Chagas, 1909) in mouse peritoneal macrophages in vitro.
    Parasitology. 1973 Apr;66(2):343-53 PMID: 4595116
  9. Cell-mediated and humoral immunity to protozoan infections.
    Transplant Rev. 1974;19(0):121-46 PMID: 4601570
  10. Observation of the interaction of peritoneal macrophages with Trypanosoma cruzi. I. Initial phase of the relationship with blood stream and culture forms in vitro.
    Rev Inst Med Trop Sao Paulo. 1973 Nov-Dec;15(6):386-92 PMID: 4599057
  11. Trypanosoma cruzi: interaction with mouse peritoneal macrophages.
    Exp Parasitol. 1972 Oct;32(2):289-300 PMID: 4560412
  12. Cell-mediated immunity against Besnoitia and toxoplasma in specifically and cross-immunized hamsters and in cultures.
    J Exp Med. 1974 Mar 1;139(3):560-80 PMID: 4812629
  13. The host response to Calmette-Guérin bacillus infection in mice.
    J Exp Med. 1969 May 1;129(5):1079-107 PMID: 4976109
  14. In vitro induction of nonspecific resistance in macrophages by specifically sensitized lymphocytes.
    Infect Immun. 1971 Oct;4(4):337-43 PMID: 5005299
  15. Cultivation and morphogenesis of Trypanosoma cruzi in improved liquid media.
    J Protozool. 1971 Nov;18(4):556-60 PMID: 4943760
  16. Cellular immunity to Leishmania donovani in macrophages in cultures.
    J Parasitol. 1969 Feb;55(1):200-7 PMID: 5764043
  17. CHRONIC AND PROGRESSIVE MYOCARDITIS AND MYOSITIS IN C3H MICE INFECTED WITH TRYPANOSOMA CRUZI.
    Am J Trop Med Hyg. 1964 Mar;13:272-80 PMID: 14125879
  18. THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE.
    J Exp Med. 1964 Jul 1;120:105-20 PMID: 14194388
  19. Factors influencing the intracellular growth of Trypanosoma cruzi in vitro.
    Am J Trop Med Hyg. 1961 Mar;10:140-54 PMID: 13728587
  20. Connective tissue reactions in normal and immunized mice to a reticulotropic strain of Trypanosoma cruzi.
    J Infect Dis. 1955 May-Jun;96(3):199-226 PMID: 14392366
  21. Intracellular multiplication of Toxoplasma gondi in adult mammalian macrophages cultivated in vitro.
    Proc Soc Exp Biol Med. 1954 Jul;86(3):413-9 PMID: 13194673
  22. Chagas' disease and Chagas' syndromes: the pathology of American trypanosomiasis.
    Adv Parasitol. 1968;6:63-116 PMID: 4239747
  23. Trypanosoma cruzi: effects of anti-thymocyte serum in mice and neonatal thymectomy in rats.
    Exp Parasitol. 1973 Oct;34(2):168-80 PMID: 4126757
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.142.2.299
Published
1975-08-01
Pages
299-311
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2189902
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.142.2.299 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2