Home LiteratureArticle Details
PMID: 8063851 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Insulin resistance, diabetes, and the insulin-regulated trafficking of GLUT-4.

The Journal of cell biology ·Vol. 126 ·No. 5 ·1994-09-00 ·Pages 1123-6

James DE, Piper RC

Abstract

暂无摘要

MeSH Terms
Adipocytes/metabolism Animals Cell Compartmentation Cell Membrane/metabolism Diabetes Mellitus, Type 2/physiopathology Glucose/metabolism Glucose Transporter Type 4 Humans Insulin/physiology Insulin Resistance Monosaccharide Transport Proteins/metabolism Muscle Proteins
Chemicals
Glucose Transporter Type 4 Insulin Monosaccharide Transport Proteins Muscle Proteins SLC2A4 protein, human Glucose
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
James D E
Center for Molecular Biology and Biotechnology, University of Queensland, St. Lucia, Brisbane, Australia.
Piper R C
References (37)
37 references, click to expand
  1. Mutational analysis of the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor. A consensus casein kinase II site followed by 2 leucines near the carboxyl terminus is important for intracellular targeting of lysosomal enzymes.
    J Biol Chem. 1993 Oct 25;268(30):22338-46 PMID: 8226743
  2. Insulin elicits a redistribution of transferrin receptors in 3T3-L1 adipocytes through an increase in the rate constant for receptor externalization.
    J Biol Chem. 1987 Jul 5;262(19):8975-80 PMID: 3298247
  3. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study.
    Lancet. 1992 Oct 17;340(8825):925-9 PMID: 1357346
  4. Transgenic mice expressing the human GLUT4/muscle-fat facilitative glucose transporter protein exhibit efficient glycemic control.
    Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11346-50 PMID: 8248251
  5. Insulin-like growth factor I and epidermal growth factor regulate the expression of transferrin receptors at the cell surface by distinct mechanisms.
    J Biol Chem. 1987 Sep 25;262(27):13126-34 PMID: 3498714
  6. The amino terminus of GLUT4 functions as an internalization motif but not an intracellular retention signal when substituted for the transferrin receptor cytoplasmic domain.
    J Cell Biol. 1994 Mar;124(5):705-15 PMID: 8120093
  7. Membrane transport: its relation to cellular metabolic rates.
    Science. 1975 Jun 20;188(4194):1177-84 PMID: 1096301
  8. Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat.
    J Cell Biol. 1991 Apr;113(1):123-35 PMID: 2007617
  9. Domains that confer intracellular sequestration of the Glut4 glucose transporter in Xenopus oocytes.
    J Biol Chem. 1993 Dec 15;268(35):26193-9 PMID: 8253739
  10. Germline manipulation of glucose homeostasis via alteration of glucose transporter levels in skeletal muscle.
    J Biol Chem. 1993 Sep 5;268(25):18442-5 PMID: 8360145
  11. Effects of insulin on steady state kinetics of GLUT4 subcellular distribution in rat adipocytes. Evidence of constitutive GLUT4 recycling.
    J Biol Chem. 1992 Sep 5;267(25):17710-5 PMID: 1517217
  12. Domains responsible for the differential targeting of glucose transporter isoforms.
    J Biol Chem. 1992 Sep 25;267(27):19636-41 PMID: 1527083
  13. Translocation of the glucose transporter (GLUT4) to the cell surface in permeabilized 3T3-L1 adipocytes: effects of ATP insulin, and GTP gamma S and localization of GLUT4 to clathrin lattices.
    J Cell Biol. 1992 Jun;117(6):1181-96 PMID: 1607382
  14. The efficient intracellular sequestration of the insulin-regulatable glucose transporter (GLUT-4) is conferred by the NH2 terminus.
    J Cell Biol. 1992 May;117(4):729-43 PMID: 1577853
  15. Insulin-regulated sorting of glucose transporters in 3T3-L1 adipocytes.
    Am J Physiol. 1992 Aug;263(2 Pt 1):E383-93 PMID: 1514622
  16. Comparison of GLUT4 and GLUT1 subcellular trafficking in basal and insulin-stimulated 3T3-L1 cells.
    J Biol Chem. 1993 Mar 5;268(7):4600-3 PMID: 8444835
  17. Phosphorylation of the glucose transporter in rat adipocytes. Identification of the intracellular domain at the carboxyl terminus as a target for phosphorylation in intact-cells and in vitro.
    J Biol Chem. 1990 Feb 5;265(4):2324-32 PMID: 2404983
  18. Localization of transferrin receptors and insulin-like growth factor II receptors in vesicles from 3T3-L1 adipocytes that contain intracellular glucose transporters.
    J Cell Biol. 1989 Apr;108(4):1537-45 PMID: 2538483
  19. Targeting of mammalian glucose transporters.
    J Cell Sci. 1993 Mar;104 ( Pt 3):607-12 PMID: 8314864
  20. Molecular biology of mammalian glucose transporters.
    Diabetes Care. 1990 Mar;13(3):198-208 PMID: 2407475
  21. Immunocytochemical and biochemical studies of GLUT4 in rat skeletal muscle.
    J Biol Chem. 1992 Mar 25;267(9):6278-85 PMID: 1556135
  22. Facilitative glucose transporters: regulatory mechanisms and dysregulation in diabetes.
    J Clin Invest. 1992 May;89(5):1367-74 PMID: 1569179
  23. Exercise induces recruitment of the "insulin-responsive glucose transporter". Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle.
    J Biol Chem. 1990 Aug 15;265(23):13427-30 PMID: 2199436
  24. Translocation of the glucose transporter GLUT4 in cardiac myocytes of the rat.
    Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7815-9 PMID: 1881917
  25. Insulin-regulated glucose uptake in rat adipocytes is mediated by two transporter isoforms present in at least two vesicle populations.
    J Biol Chem. 1989 Jul 25;264(21):12358-63 PMID: 2545707
  26. Pathogenesis of NIDDM. A balanced overview.
    Diabetes Care. 1992 Mar;15(3):318-68 PMID: 1532777
  27. Cloning of a Rab3 isotype predominantly expressed in adipocytes.
    Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):5049-52 PMID: 1594612
  28. The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi.
    J Cell Biol. 1992 Oct;119(2):249-57 PMID: 1400571
  29. Exofacial epitope-tagged glucose transporter chimeras reveal COOH-terminal sequences governing cellular localization.
    J Cell Biol. 1993 Oct;123(1):127-35 PMID: 8408193
  30. A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains.
    Cell. 1992 Jun 26;69(7):1143-57 PMID: 1535555
  31. GLUT-4 NH2 terminus contains a phenylalanine-based targeting motif that regulates intracellular sequestration.
    J Cell Biol. 1993 Jun;121(6):1221-32 PMID: 8509445
  32. Insulin stimulation of GLUT-4 translocation: a model for regulated recycling.
    Trends Cell Biol. 1994 Apr;4(4):120-6 PMID: 14731734
  33. Characterization of a major protein in GLUT4 vesicles. Concentration in the vesicles and insulin-stimulated translocation to the plasma membrane.
    J Biol Chem. 1994 Feb 25;269(8):6089-92 PMID: 8119954
  34. The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail.
    J Cell Sci. 1993 Nov;106 ( Pt 3):831-46 PMID: 8308066
  35. Transport of the lysosomal membrane glycoprotein lgp120 (lgp-A) to lysosomes does not require appearance on the plasma membrane.
    J Cell Biol. 1992 Apr;117(2):311-25 PMID: 1560028
  36. A Leu-Leu sequence is essential for COOH-terminal targeting signal of GLUT4 glucose transporter in fibroblasts.
    J Biol Chem. 1994 Jan 28;269(4):2353-6 PMID: 8300557
  37. Members of the VAMP family of synaptic vesicle proteins are components of glucose transporter-containing vesicles from rat adipocytes.
    J Biol Chem. 1992 Jun 15;267(17):11681-4 PMID: 1601842
Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.126.5.1123
Published
1994-09-00
Pages
1123-6
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2120162
Subset
IM
Grants
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1083/jcb.126.5.1123 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2