Variability of three-dimensional structure in immunoglobulins.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 3 ·1975-03-00 ·Pages 819-23

Padlan EA, Davies DR

Abstract

A comparison of various variable immunoglobulin domains demonstrates that structural variability parallels the observed frequency of amino-acid substitutions. The similarity of the structural frameworks is in good agreement with the evolutionary relationships of the chains as derived from sequence analysis.

MeSH Terms

Amino Acid Sequence Biological Evolution Immunoglobulin Heavy Chains Immunoglobulin kappa-Chains Immunoglobulins Protein Conformation

Chemicals

Immunoglobulin Heavy Chains Immunoglobulin kappa-Chains Immunoglobulins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Padlan E A

Davies D R

References (13)

13 references, click to expand

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Three-dimensional structure of the Fab' fragment of a human immunoglobulin at 2,8-A resolution.
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3305-10 PMID: 4519624
Variable region sequences of five human immunoglobulin heavy chains of the VH3 subgroup: definitive identification of four heavy chain hypervariable regions.
Proc Natl Acad Sci U S A. 1974 Mar;71(3):845-8 PMID: 4522793
The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site.
Proc Natl Acad Sci U S A. 1974 Nov;71(11):4298-302 PMID: 4530984
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Eur J Biochem. 1974 Jun 15;45(2):513-24 PMID: 4851220
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Biochemistry. 1973 Nov 6;12(23):4620-31 PMID: 4773847
The development of crystallographic enzymology.
Biochem Soc Symp. 1970;30:11-28 PMID: 4923824
Attempts to locate complementarity-determining residues in the variable positions of light and heavy chains.
Ann N Y Acad Sci. 1971 Dec 31;190:382-93 PMID: 5290024
The covalent structure of an entire gammaG immunoglobulin molecule.
Proc Natl Acad Sci U S A. 1969 May;63(1):78-85 PMID: 5257969
An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity.
J Exp Med. 1970 Aug 1;132(2):211-50 PMID: 5508247
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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.72.3.819

Published

1975-03-00

Pages

819-23

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC432411

Subset

External Links

PubMed source DOI: 10.1073/pnas.72.3.819 PMC Full Text View journal details

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Variability of three-dimensional structure in immunoglobulins.

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