Antimyelin antibodies in neurologic diseases. Immunofluorescent demonstration.

Archives of neurology ·Vol. 32 ·No. 3 ·1975-03-00 ·Pages 163-7

Lisak RP, Zwiman B, Norman M

Abstract

Antimyelin binding activity was determined in patients with multiple sclerosis, amyotrophic lateral sclerosis, other neurologic diseases, and normals. There was an increase in the group mean titer of antimyelin antibodies in patients with multiple sclerosis (MS) in acute exacerbation, amyotrophic lateral sclerosis (ALS) and Guillain-Barré syndrome. A lesser degree of binding was found in normals of all ages. There was an increase in the incidence of antimyelin antibodies in the IgM class in patients with ALS and MS. The interaction between human immunoglobulins and myelin seems to be immunologically specific and has the nature of an antigen-antibody reaction.

MeSH Terms

Acute Disease Adult Amyotrophic Lateral Sclerosis/immunology Animals Antibodies, Anti-Idiotypic Antigen-Antibody Reactions Central Nervous System/immunology Central Nervous System Diseases/immunology Child, Preschool Chronic Disease Fluorescent Antibody Technique Goats/immunology Guinea Pigs/immunology Haplorhini/immunology Humans Immunoglobulin A Immunoglobulin G Immunoglobulin M Immunoglobulins Infant Multiple Sclerosis/immunology Myelin Sheath/immunology Polyradiculopathy/immunology Rabbits/immunology Tissue Extracts

Chemicals

Antibodies, Anti-Idiotypic Immunoglobulin A Immunoglobulin G Immunoglobulin M Immunoglobulins Tissue Extracts

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Lisak R P

Zwiman B

Norman M

Article Info

Journal

Archives of neurology

Abbr.

Arch Neurol

ISSN

0003-9942

DOI

10.1001/archneur.1975.00490450043005

Published

1975-03-00

Pages

163-7

Language

English

Region

United States

NLM ID

0372436

Subset

External Links

PubMed source DOI: 10.1001/archneur.1975.00490450043005 View journal details

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