Home LiteratureArticle Details
PMID: 8041712 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Participation of cyclin A in Myc-induced apoptosis.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 15 ·1994-07-19 ·Pages 6875-9

Hoang AT, Cohen KJ, Barrett JF, Bergstrom DA, Dang CV

Abstract

The involvement of c-Myc in cellular proliferation or apoptosis has been linked to differential cyclin gene expression. We observed that in both proliferating cells and cells undergoing apoptosis, cyclin A (but not B, C, D1, and E) mRNA level was elevated in unsynchronized Myc-overexpressing cells when compared with parental Rat1a fibroblasts. We further demonstrated that Zn(2+)-inducible cyclin A expression was sufficient to cause apoptosis. When Myc-induced apoptosis was blocked by coexpression of Bcl-2, the levels of cyclin C, D1, and E mRNAs were also elevated. Thus, while apoptosis induced by c-Myc is associated with an elevated cyclin A mRNA level, protection from apoptosis by coexpressed Bcl-2 is associated with a complementary increase in cyclin C, D1, and E mRNAs.

MeSH Terms
Animals Apoptosis Cell Division Cell Line Cyclins/genetics,physiology Gene Expression Regulation Humans Proto-Oncogene Proteins c-myc/physiology RNA, Messenger/metabolism Rats Transfection Zinc/pharmacology
Chemicals
Cyclins Proto-Oncogene Proteins c-myc RNA, Messenger Zinc
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hoang A T
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Cohen K J
Barrett J F
Bergstrom D A
Dang C V
References (25)
25 references, click to expand
  1. Cooperative interaction between c-myc and bcl-2 proto-oncogenes.
    Nature. 1992 Oct 8;359(6395):554-6 PMID: 1406976
  2. Apoptotic cell death induced by c-myc is inhibited by bcl-2.
    Nature. 1992 Oct 8;359(6395):552-4 PMID: 1406975
  3. Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase.
    Cell. 1993 Aug 13;74(3):463-74 PMID: 8348613
  4. Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E.
    Mol Cell Biol. 1993 Dec;13(12):7358-63 PMID: 8246956
  5. A link between cyclin A expression and adhesion-dependent cell cycle progression.
    Science. 1993 Dec 3;262(5139):1572-5 PMID: 8248807
  6. Premature p34cdc2 activation required for apoptosis.
    Science. 1994 Feb 25;263(5150):1143-5 PMID: 8108732
  7. Activation of cyclin A-dependent protein kinases during apoptosis.
    Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3754-8 PMID: 8170983
  8. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
    Nature. 1970 Aug 15;227(5259):680-5 PMID: 5432063
  9. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.
    J Immunol. 1984 Jan;132(1):38-42 PMID: 6317746
  10. Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis.
    J Pathol. 1984 Jan;142(1):67-77 PMID: 6422024
  11. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells.
    Nature. 1988 Sep 29;335(6189):440-2 PMID: 3262202
  12. Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B.
    Nature. 1990 Aug 23;346(6286):760-3 PMID: 2143810
  13. Programmed cell death: apoptosis and oncogenesis.
    Cell. 1991 Jun 28;65(7):1097-8 PMID: 1648446
  14. Inducible transformation of fibroblasts using a metallothionein-v-myc gene construct.
    Oncogene. 1991 Jun;6(6):1073-7 PMID: 2067845
  15. Cyclins and cancer.
    Cell. 1991 Sep 20;66(6):1071-4 PMID: 1833062
  16. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast.
    Cell. 1991 Sep 20;66(6):1197-206 PMID: 1833066
  17. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.
    Oncogene. 1991 Oct;6(10):1915-22 PMID: 1923514
  18. Induction of apoptosis in fibroblasts by c-myc protein.
    Cell. 1992 Apr 3;69(1):119-28 PMID: 1555236
  19. Social controls on cell survival and cell death.
    Nature. 1992 Apr 2;356(6368):397-400 PMID: 1557121
  20. Cell cycle regulation in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe.
    Annu Rev Cell Biol. 1991;7:227-56 PMID: 1809348
  21. IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc.
    Cell. 1992 Jul 10;70(1):57-67 PMID: 1535827
  22. Cell cycle control in normal and neoplastic cells.
    Curr Opin Genet Dev. 1992 Feb;2(1):33-7 PMID: 1385997
  23. Myc and Max function as a nucleoprotein complex.
    Curr Opin Genet Dev. 1992 Apr;2(2):227-35 PMID: 1638116
  24. Function of the c-Myc oncoprotein.
    FASEB J. 1992 Sep;6(12):3065-72 PMID: 1521738
  25. Differential modulation of cyclin gene expression by MYC.
    Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3685-9 PMID: 8386381
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.91.15.6875
Published
1994-07-19
Pages
6875-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC44300
Subset
IM
Grants
NCI NIH HHS · CA51497 · United States
NCI NIH HHS · CA57341 · United States
NHLBI NIH HHS · T32HL07525 · United States
External Links
PubMed source DOI: 10.1073/pnas.91.15.6875 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2