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题目:: Characterization of adherent T cells to human endothelial cells in patients with HTLV-I-associated myelopathy.
作者:: Ichinose(K),Nakamura(T),Nishiura(Y),Nagasato(K),Ohishi(K),Watanabe(H),Fujita(A),Kurouji(K),Tsujihata(M),Nagataki(S)
状态:: 发布时间1994-07-29 , 更新时间 2006-11-15
期刊:: J Neurol Sci
摘要:: To clarify the phenomenon of increased adherence of T cells to endothelial cells (EC) in patients with HTLV-I-associated myelopathy (HAM), we determined the surface markers and expression of lymphocyte function antigen-1 (LFA-1) in T cells adherent or nonadherent to EC. The percentage of activated or HLA-DR+ T cells and the expression of LFA-1 in the adherent cell population were significantly higher than those in the nonadherent cell population. Moreover, the CD4 to CD8 ratio of the HLA-DR+ cells in the EC-adherent T cells was significantly higher than that in the nonadherent cells. Collectively, these results indicate that increased adherence of T cells to EC in HAM patients is based on the increase of activated T cells with high density LFA-1 expression in the peripheral blood. Moreover, CD4+ HLA-DR+ cells exhibited more adhesive activity to EC than CD8+ HLA-DR+ cells, suggesting that activated CD4+ cells, rather than activated CD8+ cells, may be important as the first trigger for T cell-infiltration to the central nervous system in the immunopathogenesis of HAM.
语言:: eng
DOI:

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