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PMID: 7983754 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Retinoid X receptor alpha transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor.

Journal of virology ·Vol. 69 ·No. 1 ·1995-01-00 ·Pages 547-51

Huan B, Kosovsky MJ, Siddiqui A

Abstract

The hepatitis B virus enhancer 1 contains a retinoic acid responsive element (RARE). We have previously demonstrated that retinoid X receptor alpha (RXR alpha) transactivates enhancer 1 by binding to the RARE. The present study has revealed that a heterodimeric complex composed of RXR alpha and peroxisome proliferator-activated receptor (PPAR) interacts with the hepatitis B virus RARE. Transient transfection studies, in conjunction with in vitro DNA binding data, support the hypothesis that the RXR alpha-PPAR heterodimer transactivates enhancer 1.

MeSH Terms
Base Sequence Enhancer Elements, Genetic Hepatitis B virus/genetics Molecular Sequence Data Nuclear Proteins/physiology Receptors, Cytoplasmic and Nuclear/metabolism Receptors, Retinoic Acid/physiology Retinoid X Receptors Transcription Factors/metabolism,physiology Transcriptional Activation
Chemicals
Nuclear Proteins Receptors, Cytoplasmic and Nuclear Receptors, Retinoic Acid Retinoid X Receptors Transcription Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Huan B
Department of Microbiology, University of Colorado Medical School, Denver 80262.
Kosovsky M J
Siddiqui A
References (46)
46 references, click to expand
  1. Dopaminergic and ligand-independent activation of steroid hormone receptors.
    Science. 1991 Dec 13;254(5038):1636-9 PMID: 1749936
  2. Retinoids and their receptors in differentiation, embryogenesis, and neoplasia.
    FASEB J. 1991 Nov;5(14):2924-33 PMID: 1661245
  3. Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein.
    Mol Endocrinol. 1992 Sep;6(9):1468-78 PMID: 1331778
  4. Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.
    Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):30-4 PMID: 8380496
  5. Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors.
    Nature. 1992 Jan 30;355(6359):441-6 PMID: 1310350
  6. RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.
    Genes Dev. 1994 May 1;8(9):1007-18 PMID: 7926783
  7. Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.
    Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1448-52 PMID: 1311101
  8. The mouse peroxisome proliferator activated receptor recognizes a response element in the 5' flanking sequence of the rat acyl CoA oxidase gene.
    EMBO J. 1992 Feb;11(2):433-9 PMID: 1537328
  9. Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors.
    Cell. 1992 Mar 6;68(5):879-87 PMID: 1312391
  10. Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.
    Genes Dev. 1992 Mar;6(3):329-44 PMID: 1312497
  11. RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors.
    EMBO J. 1992 Apr;11(4):1409-18 PMID: 1314167
  12. Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid.
    Nature. 1992 Aug 13;358(6387):587-91 PMID: 1323763
  13. Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase.
    Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7541-5 PMID: 1502166
  14. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors.
    Nature. 1992 Aug 27;358(6389):771-4 PMID: 1324435
  15. Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors.
    Cell. 1992 Sep 18;70(6):1007-19 PMID: 1326406
  16. Terminal differentiation in keratinocytes involves positive as well as negative regulation by retinoic acid receptors and retinoid X receptors at retinoid response elements.
    Mol Cell Biol. 1992 Nov;12(11):4862-71 PMID: 1328864
  17. Retinoid X receptor RXR alpha binds to and trans-activates the hepatitis B virus enhancer.
    Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9059-63 PMID: 1329088
  18. Long-term follow-up of chronic active hepatitis of moderate severity.
    Gut. 1978 Jun;19(6):510-3 PMID: 680585
  19. Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association.
    Prog Med Virol. 1978;24:40-69 PMID: 212785
  20. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan.
    Lancet. 1981 Nov 21;2(8256):1129-33 PMID: 6118576
  21. A human hepatitis B viral enhancer element.
    EMBO J. 1985 Feb;4(2):427-30 PMID: 3926485
  22. The human hepatitis B virus enhancer requires trans-acting cellular factor(s) for activity.
    Mol Cell Biol. 1986 Feb;6(2):710-5 PMID: 3023864
  23. Firefly luciferase gene: structure and expression in mammalian cells.
    Mol Cell Biol. 1987 Feb;7(2):725-37 PMID: 3821727
  24. The hepatitis B virus enhancer modulates transcription of the hepatitis B virus surface antigen gene from an internal location.
    J Virol. 1988 Apr;62(4):1437-41 PMID: 2831404
  25. Hepatitis B virus (HBV) promoters are regulated by the HBV enhancer in a tissue-specific manner.
    J Virol. 1989 Feb;63(2):579-83 PMID: 2536093
  26. Liver-specific expression of hepatitis B virus is determined by the combined action of the core gene promoter and the enhancer.
    J Virol. 1989 Feb;63(2):919-24 PMID: 2911125
  27. Gene regulation by steroid hormones.
    Cell. 1989 Feb 10;56(3):335-44 PMID: 2644044
  28. Cellular factors that interact with the hepatitis B virus enhancer.
    Mol Cell Biol. 1989 Apr;9(4):1804-9 PMID: 2725524
  29. Binding of nuclear factor EF-C to a functional domain of the hepatitis B virus enhancer region.
    Mol Cell Biol. 1989 Jul;9(7):2787-97 PMID: 2550788
  30. Interactions between nuclear factors and the hepatitis B virus enhancer.
    J Virol. 1989 Dec;63(12):5293-301 PMID: 2585605
  31. Luciferase reporter gene vectors for analysis of promoters and enhancers.
    Biotechniques. 1988 May;6(5):454-8 PMID: 2908509
  32. Functional organization of the hepatitis B virus enhancer.
    Mol Cell Biol. 1990 Jul;10(7):3683-9 PMID: 2355919
  33. Hierarchic and cooperative binding of the rat liver nuclear protein C/EBP at the hepatitis B virus enhancer.
    Mol Cell Biol. 1990 Aug;10(8):4427-30 PMID: 2370872
  34. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.
    Nature. 1990 Oct 18;347(6294):645-50 PMID: 2129546
  35. Regulation of the hepatitis B virus gene expression by the enhancer element I.
    Virology. 1991 Apr;181(2):721-6 PMID: 1849682
  36. Functional analysis of a liver-specific enhancer of the hepatitis B virus.
    Proc Natl Acad Sci U S A. 1991 May 1;88(9):3797-801 PMID: 1902571
  37. Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression.
    FASEB J. 1991 Jun;5(9):2243-9 PMID: 1860615
  38. Characterization of the hepatitis B virus EnhI enhancer and X promoter complex.
    J Virol. 1991 Dec;65(12):6686-92 PMID: 1658368
  39. Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor.
    Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1440-4 PMID: 8381967
  40. Transcription activation by nuclear receptors.
    J Recept Res. 1993;13(1-4):667-91 PMID: 8383765
  41. RARs and RXRs: evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo.
    EMBO J. 1993 Jun;12(6):2349-60 PMID: 8389696
  42. Functional interaction of nuclear factors EF-C, HNF-4, and RXR alpha with hepatitis B virus enhancer I.
    J Virol. 1993 Jul;67(7):3940-50 PMID: 8389913
  43. The erbA oncogene represses the actions of both retinoid X and retinoid A receptors but does so by distinct mechanisms.
    Mol Cell Biol. 1993 Oct;13(10):5970-80 PMID: 8105369
  44. RFX1 is identical to enhancer factor C and functions as a transactivator of the hepatitis B virus enhancer.
    Mol Cell Biol. 1993 Oct;13(10):6375-84 PMID: 8413236
  45. Formation of retinoid X receptor homodimers leads to repression of T3 response: hormonal cross talk by ligand-induced squelching.
    Mol Cell Biol. 1993 Dec;13(12):7698-707 PMID: 8246986
  46. Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling.
    Nature. 1992 Jan 30;355(6359):446-9 PMID: 1310351
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.69.1.547-551.1995
Published
1995-01-00
Pages
547-51
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC188608
Subset
IM
Grants
NCI NIH HHS · CA65671 · United States
External Links
PubMed source DOI: 10.1128/JVI.69.1.547-551.1995 PMC Full Text View journal details
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